Journal ArticleDOI
Lifetime lead intoxication: influence on the amygdaloid kindling model of epileptogenesis.
TLDR
It is suggested that, although lead intoxication starting in neonatal life does not appear to affect the susceptibility to development of amygdaloid kindled seizures, it may enhance seizure severity in this model of epileptogenesis.About:
This article is published in Toxicology.The article was published on 1985-07-01. It has received 7 citations till now. The article focuses on the topics: Seizure threshold & Lead acetate.read more
Citations
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Journal ArticleDOI
Pharmacological studies with a GABA uptake inhibitor in rats with kindled seizures in the amygdala.
M.C. Heit,W.S. Schwark +1 more
TL;DR: The characterization of a biphasic kindled seizure allows for speculation regarding the role of GABAergic mechanisms in its pathogenesis and of the mechanism of action of SKF 89976-A.
Journal ArticleDOI
Prevention of amygdala kindling with an inhibitor of γ-aminobutyric acid uptake
TL;DR: The data suggest that SKF 89976-A can inhibit generalization of amygdala-kindled seizures, possibly by enhancement of central GABAergic activity.
Journal ArticleDOI
Effect of short-term lead exposure on PTZ-induced seizure threshold in mice.
TL;DR: It may be concluded that 100 ppm of lead was the minimal effective dose and lead acetate at a concentration of 100 ppm that produces similar blood level in human populations approves the enhancement of convulsive attack risk.
Journal ArticleDOI
Prolonged Exposure to Lead Lowers the Threshold of Pentylenetetrazole‐induced Seizures in Rats
Oscar Arrieta,Guadalupe Palencia,Guadalupe García-Arenas,Daniela Morales-Espinosa,Norma Hernández-Pedro,Julio Sotelo +5 more
TL;DR: The aim of this work was to study the effects of prolonged exposure to lead on the threshold of experimental seizures induced by pentylenetetrazole (PTZ).
Journal ArticleDOI
Developmental lead exposure differentially alters the susceptibility to chemoconvulsants in rats
Hwei-Hsien Chen,Ming-Huan Chan +1 more
TL;DR: The results demonstrate that developmental Pb exposure does not result in a global and persistent lowering of threshold in response to convulsive stimuli and the Pb-induced changes may be due to a selective modulation of inhibitory and excitatory neurotransmission depending on age and Pb concentration in blood.
References
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Journal ArticleDOI
Modification of seizure activity by electrical stimulation. II. Motor seizure.
TL;DR: It was found that the development of motor seizures by stimulation of the amygdala resulted in an increased ability of the contralateral amygdala, and the septal area, but not of the hippocampus, to drive motor seizures when stimulated (“transfer”).
Journal ArticleDOI
Lead encephalo-myelopathy of the suckling rat and its implications on the porphyrinopathic nervous diseases
A. Pentschew,F. Garro +1 more
TL;DR: Experimental lead encephalo-myelopathy of the suckling rat is the signpost on the tortuous road of uncovering prolonged metabolic dysoxidosis as the major pathogenetic principle in lead encephalopathy and in the other porphyrinopathic encephalopathies.
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Neurologic Sequelae of Plumbism in Children
Meyer A. Perlstein,Ramzy Attala +1 more
TL;DR: A survey on the nature and in cidence of the neurologic sequelae of lead intoxication among 425 patients over a ten-year period.
Journal ArticleDOI
Role of forebrain catecholamines in amygdaloid kindling.
TL;DR: The results are consistent with previous evidence that noradrenaline reduces the susceptibility of the central nervous system to epileptiform activity, and they suggest that a lessening of seizure-suppressantnoradrenergic function in the forebrain might be part of the mechanism underlying kindling.
Related Papers (5)
Kindling in developing rats: persistence of seizures into adulthood.
Solomon L. Moshé,Bruce Albala +1 more
A single neonatal pentylenetetrazol or hyperthermia convulsion increases kindling susceptibility in the adult rat.
Mary E. Gilbert,Donald P. Cain +1 more