Journal ArticleDOI
Modification of seizure activity by electrical stimulation. II. Motor seizure.
TLDR
It was found that the development of motor seizures by stimulation of the amygdala resulted in an increased ability of the contralateral amygdala, and the septal area, but not of the hippocampus, to drive motor seizures when stimulated (“transfer”).About:
This article is published in Electroencephalography and Clinical Neurophysiology.The article was published on 1972-03-01. It has received 6638 citations till now. The article focuses on the topics: Seizure threshold & Kindling model.read more
Citations
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Two-stage model of memory trace formation: a role for "noisy" brain states.
TL;DR: It is suggested that the strong excitatory drive brought about by the sharp wave-concurrent population bursts during consummatory behaviors, immobility, and slow wave sleep may be sufficient for the induction of long-term synaptic modification in the initiator neurons of the CA3 region and in their targets in CA1.
Journal ArticleDOI
Modification of seizure activity by electrical stimulation: III. Mechanisms
TL;DR: It was found that stimulation of more than one area increases the rate of seizure development, whereas disrupting inter-limbic connections retards seizure development.
Journal ArticleDOI
Aberrant Excitatory Neuronal Activity and Compensatory Remodeling of Inhibitory Hippocampal Circuits in Mouse Models of Alzheimer's Disease
Jorge J. Palop,Jeannie Chin,Erik D. Roberson,Jun Wang,Myo T. Thwin,Nga Bien-Ly,Jong Yoo,Kaitlyn Ho,Gui-Qiu Yu,Anatol C. Kreitzer,Steven Finkbeiner,Jeffrey L. Noebels,Lennart Mucke +12 more
TL;DR: It is reported that hAPP mice have spontaneous nonconvulsive seizure activity in cortical and hippocampal networks, which is associated with GABAergic sprouting, enhanced synaptic inhibition, and synaptic plasticity deficits in the dentate gyrus.
Journal ArticleDOI
The pilocarpine model of temporal lobe epilepsy.
TL;DR: It is proposed that the pilocarpine model can be a valuable tool to investigate the mechanisms involved in TLE, and even more so when standardized to reduce mortality at the time of pilocARPine injection, differences in latent period duration, variability in the lesion extent, and SRS frequency.
Journal ArticleDOI
Absence of CNTNAP2 Leads to Epilepsy, Neuronal Migration Abnormalities, and Core Autism-Related Deficits
Olga Peñagarikano,Brett S. Abrahams,Brett S. Abrahams,Edward I. Herman,Kellen D. Winden,Amos Gdalyahu,Hongmei Dong,Lisa I. Sonnenblick,Robin Gruver,Joel Almajano,Anatol Bragin,Peyman Golshani,Joshua T. Trachtenberg,Elior Peles,Daniel H. Geschwind,Daniel H. Geschwind +15 more
TL;DR: A mouse knockout of the Cntnap2 gene is characterized, which is strongly associated with ASD and allied neurodevelopmental disorders, and treatment with the FDA-approved drug risperidone ameliorates the targeted repetitive behaviors in the mutant mice.
References
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Journal ArticleDOI
A permanent change in brain function resulting from daily electrical stimulation.
TL;DR: High-intensity stimulation studies revealed that the development of convulsions was not based simply on threshold reduction, but involved complex reorganization of function.
Journal ArticleDOI
Cortical cellular phenomena in experimental epilepsy: interictal manifestations.
H. Matsumoto,C A Marsan +1 more
TL;DR: An intracellular analysis from the involved elements was carried out during the development and course of the organized rhythmical electrographic seizures simultaneously monitored with surface electrodes, finding that some neurons appear to be activated only in the later phases of the seizure.
Journal ArticleDOI
Modification of seizure activity by electrical stimulation. I. After-discharge threshold.
TL;DR: Rats with multiple recording and stimulating electrodes were stimulated electrically in the amygdala, hippocampus and reticular formation to determine the threshold at which after-discharges were produced in the vicinity of the stimulating electrode, and reduction of AD thresholds resulted in an increase in the AD threshold in the contralateral hippocampus.
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Penicillin-induced interictal discharges from the cat hippocampus. I. Characteristics and topographical features.
M Dichter,W A Spencer +1 more
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Evolution of repeated hippocampal seizures in the cat
TL;DR: In unanesthetized cats, with permanent intracerebral electrodes, as many as 100 repeated hippocampal after-discharges (HAD's) were evoked during a period of 15–30 days, and a clear correlation was established between motor participation of the face and 4–6 c/sec activity of the amygdala.