Journal ArticleDOI
Long-term antidepressant treatment decreases spiroperidol-labeled serotonin receptor binding
TLDR
The decrease in the number of receptor sites is most marked for [3H]spiroperidol-labeled serotonin receptors and is characteristic for antidepressants of several classes.Abstract:
Antidepressants compete at several neurotransmitter receptor binding site, but drug affinities do not correlate with clinical efficacy. Long-term, but not short-term, antidepressant treatment decreases the numbers of both serotonin and beta-adrenergic receptors. The decrease in the number of receptor sites is most marked for [3H]spiroperidol-labeled serotonin receptors and is characteristic for antidepressants of several classes.read more
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A molecular and cellular theory of depression
TL;DR: These findings constitute the framework for an updated molecular and cellular hypothesis of depression, which posits that stress-induced vulnerability and the therapeutic action of antidepressant treatments occur via intracellular mechanisms that decrease or increase, respectively, neurotrophic factors necessary for the survival and function of particular neurons.
Journal ArticleDOI
Quantitative autoradiographic mapping of serotonin receptors in the rat brain. I. Serotonin-1 receptors.
Angel Pazos,José Palacios +1 more
TL;DR: The distribution of serotonin-1 (5-HT1) receptors in the rat brain was studied by light microscopic quantitative autoradiography and the existence of 'selective' areas allowed a detailed pharmacological characterization of these sites to be made in a more precise manner than has been attained in membrane-binding studies.
Book
Brainstem control of wakefulness and sleep
TL;DR: A monograph communicating the current realities and future possibilities of unifying basic studies on anatomy and cellular physiology with investigations of the behavioral and physiological events of waking and sleep.
Journal ArticleDOI
The Effects of Clozapine, Risperidone, and Olanzapine on Cognitive Function in Schizophrenia
TL;DR: Atypical antipsychotic drugs as a group appear to be superior to typical neuroleptics with regard to cognitive function, however, available data suggest that these drugs produce significant differences in specific cognitive functions.
Journal ArticleDOI
Localization of novel corticotropin-releasing factor receptor (CRF2) mRNA expression to specific subcortical nuclei in rat brain: comparison with CRF1 receptor mRNA expression
TL;DR: The anatomical distribution of CRF2 receptor mRNA indicates a role for this novel receptor in hypothalamic neuroendocrine, autonomic and general behavioral actions of central CRF and suggests distinctive functional roles for each receptor in CRF-related systems.
References
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Journal Article
Multiple Serotonin Receptors: Differential Binding of [3H]5-Hydroxytryptamine, [3H]Lysergic Acid Diethylamide and [3H]Spiroperidol
TL;DR: It is proposed that [3H]5-HT and[3H]-spiroperidol label distinct populations of serotonin receptors in rat brain, designated 5-HT1 and 5- HT2 receptors, respectively.
Journal ArticleDOI
Antischizophrenic drugs: chronic treatment elevates dopamine receptor binding in brain
TL;DR: Chronic treatment of rats with the neuroleptic drugs haloperidol, fluphenazine, and reserpine elicits a 20 to 25% increase in striatal dopamine receptor binding assayed with [3H]haloperidols, which may account for behavioral supersensitivity to dopamine receptor stimulants in such animals and for tardive dyskinesia in patients treated with these drugs.
Journal ArticleDOI
Development of β-adrenergic receptor subsensitivity by antidepressants
TL;DR: The purpose of the experiments described here was to explore the molecular basis for antidepressant-induced noradrenergic subsensitivity by examining the kinetic properties of the β-ADrenergic receptors in the microsomal suspension of rat brain by using a potent β- adrenergic receptor antagonist 3H-dihydroalprenolol as a radiolabelled ligand, and results indicate that the main mechanism is a reduction in the number of receptors.
Journal ArticleDOI
Tricyclic antidepressants: long-term treatment increases responsivity of rat forebrain neurons to serotonin
TL;DR: The enhanced response to serotonin induced by the clinically active tricyclic drugs took 1 to 2 weeks to develop, a time course which correlates with the delayed onset of therapeutic effects in humans.
Journal Article
Presynaptic modulation of beta adrenergic receptors in rat cerebral cortex after treatment with antidepressants.
TL;DR: These experiments suggest that antidepressants, acting presynaptically, increase the concentration of transmitter at noradrenergic synapses and induce a compensatory decrease in the density of beta adrenergic receptors.
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Development of β-adrenergic receptor subsensitivity by antidepressants
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