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Quantitative autoradiographic mapping of serotonin receptors in the rat brain. I. Serotonin-1 receptors.
Angel Pazos,José Palacios +1 more
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The distribution of serotonin-1 (5-HT1) receptors in the rat brain was studied by light microscopic quantitative autoradiography and the existence of 'selective' areas allowed a detailed pharmacological characterization of these sites to be made in a more precise manner than has been attained in membrane-binding studies.About:
This article is published in Brain Research.The article was published on 1985-11-04. It has received 1866 citations till now. The article focuses on the topics: Dorsal raphe nucleus & Ventral pallidum.read more
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A review of central 5-HT receptors and their function
Nicholas M. Barnes,Trevor Sharp +1 more
TL;DR: A number of 5-HT receptor ligands are currently utilised, or are in clinical development, to reduce the symptoms of CNS dysfunction and the functional responses attributed to each receptor in the brain are reviewed.
Journal ArticleDOI
Descending control of pain.
TL;DR: The present review focuses on the organisation of descending pathways and their pathophysiological significance, the role of individual transmitters and specific receptor types in the modulation and expression of mechanisms of descending inhibition and facilitation and the advantages and limitations of established and innovative analgesic strategies which act by manipulation of descending controls.
Journal ArticleDOI
Endocannabinoid-Mediated Control of Synaptic Transmission
TL;DR: This review aims to integrate the current understanding of functions of the endocannabinoid system, especially focusing on the control of synaptic transmission in the brain, and summarizes recent electrophysiological studies carried out on synapses of various brain regions and discusses how synaptic transmission is regulated by endoc cannabinoidoid signaling.
Journal ArticleDOI
Risperidone compared with new and reference antipsychotic drugs: in vitro and in vivo receptor binding
A. Schotte,P.F.M. Janssen,W. Gommeren,Walter Luyten,P. Van Gompel,A S Lesage,K. De Loore,J. E. Leysen +7 more
TL;DR: In vitro, all compounds, except the ‘typical’ antipsychotics haloperidol and fluspirilene, showed higher affinity for 5HT2A than for D2 receptors, while in vivo, ORG-5222, risperidone, pipamperone, 9-OH-risperid one, sertindole, olanzapine, zotepine and clozapine maintained a higher potency for occupying 5HT
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Molecular biology of 5-HT receptors
F.G. Boess,I.L. Martin +1 more
TL;DR: The receptors through which serotonin (5-hydroxytryptamine, 5-HT) produces its effects have been the subject of intense investigation, initially using both in vivo and in vitro pharmacological methods, and later radioligand binding.
References
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The Rat Brain in Stereotaxic Coordinates
George Paxinos,Charles Watson +1 more
TL;DR: This paper presents a meta-analyses of the determinants of earthquake-triggered landsliding in the Czech Republic over a period of 18 months in order to establish a probabilistic framework for estimating the intensity of the earthquake.
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Evidence for the existence of monoamine-containing neurons in the central nervous system. i. demonstration of monoamines in the cell bodies of brain stem neurons.
Dahlstroem A,Fuxe K +1 more
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A "direct-coloring" thiocholine method for cholinesterases
Morris J. Karnovsky,Logan Roots +1 more
TL;DR: Colour is prooduced directly at the site of eoozyusuatic activity, facilitating estinsation of h.hue ooptinuuius imscusi)soti000s tinse; the l)necipitate is finselv grssusuulan, so) lhooot, eveos witis prolonged incusbosoh booms, needle-like deposits are not ob)served; instemuse cnol(on s
Journal ArticleDOI
Dynamic response of chest wall and lung injuries in rabbits exposed to air shock waves of short duration.
Carl-Johan Clemedson,Joensson A +1 more
TL;DR: The chest walls of rabbits exposed to steep-fronted air shock waves of short duration produced by 50 g spherical charges of TNT were recorded by means of a mechano-electric motion transducer to study the correlation between the deformations of the chest and the damage inflicted to the underlying organs, especially the lungs.
Journal ArticleDOI
Distribution of serotonin-immunoreactivity in the central nervous system of the rat-cell bodies and terminals.
TL;DR: The results demonstrate a widespread occurrence of 5-HT-positive nerve terminals throughout the central nervous system and the finding that serotonin-containing neurons are present in many nuclei that also include catecholamine- containing neurons makes it necessary to reconsider the terminology of the monoaminergic cell groups.