Journal ArticleDOI
Low-Level Laser Therapy Induces Dose-Dependent Reduction of TNFα Levels in Acute Inflammation
Flavio Aimbire,Regiane Albertini,M.T.T. Pacheco,Hugo C. Castro-Faria-Neto,P. S. L. M. Leonardo,Vegard Vereide Iversen,Rodrigo Álvaro Brandão Lopes-Martins,Jan Magnus Bjordal +7 more
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TLDR
LLLT can reduce TNFalpha expression after acute immunocomplex lung injury in rats, but LLLT dose appears to be critical for reducing TNF alpha release.Abstract:
Objective: The aim of this study was to investigate if low-level laser therapy (LLLT) can modulate acute inflammation and tumor necrosis factor (TNFα) levels. Background Data: Drug therapy with TNFα-inhibitors has become standard treatment for rheumatoid arthritis, but it is unknown if LLLT can reduce or modulate TNFα levels in inflammatory disorders. Methods: Two controlled animal studies were undertaken, with 35 male Wistar rats randomly divided into five groups each. Rabbit antiserum to ovalbumin was instilled intrabronchially in one of the lobes, followed by the intravenous injection of 10 mg of ovalbumin in 0.5 mL to induce acute lung injury. The first study served to define the time profile of TNFα activity for the first 4 h, while the second study compared three different LLLT doses to a control group and a chlorpromazine group at a timepoint where TNFα activity was increased. The rats in LLLT groups were irradiated within 5 min at the site of injury by a 650-nm Ga-Al-As laser. Results: There was a...read more
Citations
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Journal ArticleDOI
Biphasic Dose Response in Low Level Light Therapy
TL;DR: The molecular and cellular mechanisms in LLLT are covered, and some of the recent results in vitro and in vivo that provide scientific explanations for this biphasic dose response are described.
Journal ArticleDOI
Efficacy of low-level laser therapy in the management of neck pain: a systematic review and meta-analysis of randomised placebo or active-treatment controlled trials
Roberta T. Chow,Mark I. Johnson,Rodrigo Álvaro Brandão Lopes-Martins,Jan Magnus Bjordal,Jan Magnus Bjordal +4 more
TL;DR: It is shown that LLLT reduces pain immediately after treatment in acute neck pain and up to 22 weeks after completion of treatment in patients with chronic neck pain.
Journal ArticleDOI
Low-level laser therapy in acute pain: a systematic review of possible mechanisms of action and clinical effects in randomized placebo-controlled trials.
Jan Magnus Bjordal,Mark I. Johnson,Vegard Vereide Iversen,Flavio Aimbire,Rodrigo Álvaro Brandão Lopes-Martins +4 more
TL;DR: Photoradiation can modulate inflammatory processes in a dose-dependent manner and can be titrated to significantly reduce acute inflammatory pain in clinical settings.
Journal ArticleDOI
Molecular mechanisms of cell proliferation induced by low power laser irradiation.
Xuejuan Gao,Da Xing +1 more
TL;DR: Hepatocyte growth factor receptor (c-Met), a member of tyrosine protein kinase receptors (TPKR), is phosphorylated during LPLI-induced proliferation, but tumor necrosis factor alpha (TNF-alpha) receptor has not been affected.
Journal Article
Efficacy of low-level laser therapy in the management of neck pain: a systematic review and meta-analysis of randomised placebo or active-treatment controlled trials
TL;DR: Low-level laser therapy (LLLT) is a relatively uncommon, non-invasive treatment for neck pain, in which non-thermal laser irradiation is applied to sites of pain this article.
References
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Photobiology of low-power laser effects.
TL;DR: It is proposed that enhanced wound healing due to irradiation with low-intensity visible laser light (He-Cd, He-Ne and semiconductor lasers) is due to the increasing proliferation of cells.
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Inhibitory effect of low-level laser irradiation on LPS-stimulated prostaglandin E2 production and cyclooxygenase-2 in human gingival fibroblasts.
TL;DR: The findings suggest that low-level laser irradiation may be of therapeutic benefit against the aggravation of gingivitis and periodontitis by bacterial infection.
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The role of eosinophils and neutrophils in inflammation
TL;DR: Evidence from the ENFUMOSA project and elsewhere suggests that neutrophils not only contribute to acute asthma exacerbations, but also are present in high numbers in the airways of patients with chronic severe asthma.
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The Efficacy of Laser Therapy for Musculoskeletal and Skin Disorders: A Criteria-Based Meta-analysis of Randomized Clinical Trials
TL;DR: The efficacy of laser therapy for musculoskeletal disorders seems, on average, to be larger than the efficacy of a placebo treatment, and for rheumatoid arthritis, posttraumatic joint disorders, and myofascial pain, laser therapy seems to have a substantial specific therapeutic effect.
Journal ArticleDOI
Inhibition of prostaglandin E2 and interleukin 1-beta production by low-power laser irradiation in stretched human periodontal ligament cells.
Noriyoshi Shimizu,Masaru Yamaguchi,Takemi Goseki,Yasuko Shibata,Hisashi Takiguchi,Tadamasa Iwasawa,Yoshimitsu Abiko +6 more
TL;DR: Its inhibitory effects on PGE2 and IL-1β production suggest that laser irradiation may have great therapeutic benefits in bringing about relief of the pain that accompanies orthodontic treatment.