H
Hugo C. Castro-Faria-Neto
Researcher at Oswaldo Cruz Foundation
Publications - 207
Citations - 7990
Hugo C. Castro-Faria-Neto is an academic researcher from Oswaldo Cruz Foundation. The author has contributed to research in topics: Inflammation & Sepsis. The author has an hindex of 47, co-authored 193 publications receiving 6978 citations. Previous affiliations of Hugo C. Castro-Faria-Neto include Estácio S.A. & University of Utah.
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Journal ArticleDOI
Cytokine profiles as markers of disease severity in sepsis: a multiplex analysis
Fernando A. Bozza,Fernando A. Bozza,Jorge I. F. Salluh,André M. Japiassú,André M. Japiassú,Marcio Soares,Edson F. Assis,Rachel N. Gomes,Marcelo T. Bozza,Hugo C. Castro-Faria-Neto,Patrícia T. Bozza +10 more
TL;DR: In this article, the authors used a multiplex system for simultaneous detection of 17 cytokines (IL-1β, IL-2, IL 4, IL 5, IL 6, IL 7, IL 8, IL 9, IL 10, IL 11, IL 12, IL 13, interferon-γ, MCP-1, macrophage inflammatory protein-1 and tumour necrosis factor-α).
Journal ArticleDOI
Uptake of apoptotic cells drives the growth of a pathogenic trypanosome in macrophages.
Celio Geraldo Freire-de-Lima,Danielle Oliveira Nascimento,Milena Botelho Pereira Soares,Patrícia T. Bozza,Hugo C. Castro-Faria-Neto,F.G. de Mello,George A. DosReis,Marcela F. Lopes +7 more
TL;DR: The results suggest that continual lymphocyte apoptosis and phagocytosis of apoptotic cells by macrophages have a role in parasite persistence in the host, and that cyclooxygenase inhibitors have potential therapeutic application in the control of parasite replication and spread in Chagas' disease.
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Mycobacterium bovis bacillus Calmette-Guérin induces TLR2-mediated formation of lipid bodies: intracellular domains for eicosanoid synthesis in vivo.
Heloisa D'Avila,Rossana C. N. Melo,Gleydes G. Parreira,Eduardo Werneck-Barroso,Hugo C. Castro-Faria-Neto,Patrícia T. Bozza +5 more
TL;DR: It is demonstrated that BCG-induced lipid body formation is TLR2 mediated and these structures function as signaling platforms in inflammatory mediator production, because compartmentalization of substrate and key enzymes within lipid bodies has impact on the capacity of activated leukocytes to generate increased amounts of eicosanoids during experimental infection by BCG.
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Low-Level Laser Therapy Induces Dose-Dependent Reduction of TNFα Levels in Acute Inflammation
Flavio Aimbire,Regiane Albertini,M.T.T. Pacheco,Hugo C. Castro-Faria-Neto,P. S. L. M. Leonardo,Vegard Vereide Iversen,Rodrigo Álvaro Brandão Lopes-Martins,Jan Magnus Bjordal +7 more
TL;DR: LLLT can reduce TNFalpha expression after acute immunocomplex lung injury in rats, but LLLT dose appears to be critical for reducing TNF alpha release.
Journal ArticleDOI
Inflammatory Platelet-activating Factor-like Phospholipids in Oxidized Low Density Lipoproteins Are Fragmented Alkyl Phosphatidylcholines
Gopal K. Marathe,Sean S. Davies,Kathleen A. Harrison,Adriana R. Silva,Robert C. Murphy,Hugo C. Castro-Faria-Neto,Stephen M. Prescott,Stephen M. Prescott,Guy A. Zimmerman,Thomas M. McIntyre +9 more
TL;DR: Results show that quite minor constituents of the LDL phosphatidylcholine pool are the exclusive precursors for PAF-like bioactivity in oxidized LDL.