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Hugo C. Castro-Faria-Neto

Researcher at Oswaldo Cruz Foundation

Publications -  207
Citations -  7990

Hugo C. Castro-Faria-Neto is an academic researcher from Oswaldo Cruz Foundation. The author has contributed to research in topics: Inflammation & Sepsis. The author has an hindex of 47, co-authored 193 publications receiving 6978 citations. Previous affiliations of Hugo C. Castro-Faria-Neto include Estácio S.A. & University of Utah.

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Cytokine profiles as markers of disease severity in sepsis: a multiplex analysis

TL;DR: In this article, the authors used a multiplex system for simultaneous detection of 17 cytokines (IL-1β, IL-2, IL 4, IL 5, IL 6, IL 7, IL 8, IL 9, IL 10, IL 11, IL 12, IL 13, interferon-γ, MCP-1, macrophage inflammatory protein-1 and tumour necrosis factor-α).
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Uptake of apoptotic cells drives the growth of a pathogenic trypanosome in macrophages.

TL;DR: The results suggest that continual lymphocyte apoptosis and phagocytosis of apoptotic cells by macrophages have a role in parasite persistence in the host, and that cyclooxygenase inhibitors have potential therapeutic application in the control of parasite replication and spread in Chagas' disease.
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Mycobacterium bovis bacillus Calmette-Guérin induces TLR2-mediated formation of lipid bodies: intracellular domains for eicosanoid synthesis in vivo.

TL;DR: It is demonstrated that BCG-induced lipid body formation is TLR2 mediated and these structures function as signaling platforms in inflammatory mediator production, because compartmentalization of substrate and key enzymes within lipid bodies has impact on the capacity of activated leukocytes to generate increased amounts of eicosanoids during experimental infection by BCG.