Journal ArticleDOI
Manganese and Lipoflavonoid Plus(®) to Treat Tinnitus: A Randomized Controlled Trial.
Eveling Rojas-Roncancio,Richard S. Tyler,Hyung-Jin Jun,Tang-Chuan Wang,Haihong Ji,Claudia Coelho,Shelley Witt,Marlan R. Hansen,Bruce J. Gantz +8 more
TLDR
It was not able to conclude that either manganese or Lipoflavonoid Plus(®) is an effective treatment for tinnitus.Abstract:
BACKGROUND Several tinnitus sufferers suggest that manganese has been helpful with their tinnitus. PURPOSE We tested this in a controlled experiment where participants were committed to taking manganese and Lipoflavonoid Plus(®) to treat their tinnitus. RESEARCH DESIGN Randomized controlled trial. STUDY SAMPLE 40 participants were randomized to receive both manganese and Lipoflavonoid Plus(®) for 6 months, or Lipoflavonoid Plus(®) only (as the control). DATA COLLECTION AND ANALYSIS Pre- and postmeasures were obtained with the Tinnitus Handicap Questionnaire, Tinnitus Primary Functions Questionnaire, and tinnitus loudness and annoyance ratings. An audiologist performed the audiogram, the tinnitus loudness match, and minimal masking level. RESULTS Twelve participants were dropped out of the study because of the side effects or were lost to follow-up. In the manganese group, 1 participant (out of 12) showed a decrease in the questionnaires, and another showed a decrease in the loudness and annoyance ratings. No participants from the control group (total 16) showed a decrease in the questionnaires ratings. Two participants in the control group reported a loudness decrement and one reported an annoyance decrement. CONCLUSIONS We were not able to conclude that either manganese or Lipoflavonoid Plus(®) is an effective treatment for tinnitus.read more
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Journal ArticleDOI
Survey on the Effectiveness of Dietary Supplements to Treat Tinnitus
Claudia Coelho,Richard S. Tyler,Haihong Ji,Eveling Rojas-Roncancio,Shelley Witt,Pan Tao,Hyung-Jin Jun,Tang-Chuan Wang,Marlan R. Hansen,Bruce J. Gantz +9 more
TL;DR: It is concluded that dietary supplements should not be recommended to treat tinnitus but could have a positive outcome onTinnitus reactions in some people.
Journal ArticleDOI
Noise Induced Hearing Loss and Tinnitus-New Research Developments and Remaining Gaps in Disease Assessment, Treatment, and Prevention.
Tang-Chuan Wang,Ta-Yuan Chang,Richard S. Tyler,Ying Ju Lin,Wen-Miin Liang,Yio-Wha Shau,Wei-Yong Lin,Yi-Wen Chen,Chia-Der Lin,Ming Hsui Tsai +9 more
TL;DR: increasing knowledge of neural plasticity and adaptive changes in the central auditory system suggest that NIHL is preventable and transient abnormalities may be reversable, although ongoing research in assessment and early detection of hearing difficulties is still urgently needed.
Journal ArticleDOI
Methodological Aspects of Randomized Controlled Trials for Tinnitus: A Systematic Review and How a Decision Support System Could Overcome Barriers.
Dimitrios Kikidis,Evgenia Vassou,Winfried Schlee,Eleftheria Iliadou,Nikolaos Markatos,Aikaterini Triantafyllou,Berthold Langguth +6 more
TL;DR: In this paper, the authors identified, summarized, and critically appraised tinnitus-related randomized clinical trials since 2010, aiming at systematically mapping the research conducted in this area, and provided important insight on the identification of limitations of previous works, methodological pitfalls or gaps in current knowledge, a prerequisite for the adequate interpretation of current literature and execution of future studies.
Journal ArticleDOI
Reliability and validity of the mandarin version of the tinnitus primary function questionnaire: A preliminary observational study.
Tao Lu,Jie-Hai Liu,Gang Li,Ting Xiang,Ying Ma,Juan Zhong,Jia-Mei Chen,Yu-Rui He,He-Mei Huang,Zong-Yun Zhang,Pan Liu,Yun Zheng +11 more
TL;DR: The reliability and validity of the Mandarin Tinnitus Primary Function Questionnaire (TPFQ-M) in a Chinese population was evaluated and it was found that a 4-factor model was close to fit.
Journal ArticleDOI
Micronutrients in tinnitus: A National Health and Nutrition Examination Survey analysis.
TL;DR: In this paper , the influence of low serum/blood levels of zinc, manganese, and vitamin B12 on tinnitus presence, regularity, and disruptiveness was investigated.