Journal ArticleDOI
Mapping Catechol-O-Methyltransferase in vivo: Initial studies with [18F]RO41-0960
Yu-Shin Ding,Samuel J. Gatley,Joanna S. Fowler,Ruoyan Chen,Nora D. Volkow,Nora D. Volkow,Jean Logan,Colleen Shea,Y. Sugano,J. Koomen +9 more
TLDR
Positron emission tomographic studies in baboon and studies in mice provide the first example of a positron emitter labeled radiotracer for COMT, and initial encouraging evidence that [18F]Ro41-0960 may be used to examine COMT in peripheral organs in vivo.About:
This article is published in Life Sciences.The article was published on 1995-12-08. It has received 21 citations till now. The article focuses on the topics: COMT inhibitor & Catechol-O-methyl transferase.read more
Citations
More filters
Journal Article
Catechol-O-methyltransferase (COMT): biochemistry, molecular biology, pharmacology, and clinical efficacy of the new selective COMT inhibitors.
Pekka T. Männistö,Seppo Kaakkola +1 more
TL;DR: The enzyme responsible for the O- methylation, catechol- O -methyltransferase (COMT) was partly purified and characterized by the same group as EC, which first described the enzyme-catalyzed O-methylation of catechlamines and other catechols in the late 1950s.
Journal Article
PET and drug research and development.
TL;DR: PET is in a unique position to contribute significantly to the process of drug development through understanding the molecular mechanisms underlying drug action while addressing some very practical questions such as determining effective drug doses for clinical trials for new drugs, determining the duration of drug action and examining potential drug interactions.
Journal ArticleDOI
Kinetics and Crystal Structure of Catechol-O-Methyltransferase Complex with Co-Substrate and a Novel Inhibitor with Potential Therapeutic Application
Maria João Bonifácio,Margarida Archer,M. L. Rodrigues,Pedro M. Matias,David Alexander Learmonth,Maria Arménia Carrondo,Patrício Soares-da-Silva +6 more
TL;DR: This is the first report of a three-dimensional structure determination of COMT complexed with a potent, reversible, and tight-binding inhibitor that is expected to have therapeutic applications.
Journal ArticleDOI
Biochemical and molecular modeling studies of the O-methylation of various endogenous and exogenous catechol substrates catalyzed by recombinant human soluble and membrane-bound catechol-O-methyltransferases.
TL;DR: In this article, the authors have cloned and expressed human soluble and membrane-bound COMTs in Escherichia coli and have studied their biochemical characteristics for the O-methylation of a wide array of catechol-containing substrates using s-adenosyl-l-methionine as the methyl donor.
Journal ArticleDOI
Comparative evaluation of positron emission tomography radiotracers for imaging the norepinephrine transporter: (S,S) and (R,R) enantiomers of reboxetine analogs ([11C]methylreboxetine, 3-Cl-[11C]methylreboxetine and [18F]fluororeboxetine), (R)-[11C]nisoxetine, [11C]oxaprotiline and [11C]lortalamine.
TL;DR: (S,S)‐[11C]MRB remains by far the most promising NET ligand for PET studies.
References
More filters
Journal ArticleDOI
Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites.
Carlos Cordon-Cardo,James P. O'Brien,Dolors Casals,Lana Rittman-Grauer,June L. Biedler,Myron R. Melamed,Joseph R. Bertino +6 more
TL;DR: P-glycoprotein expression in capillary endothelium of brain and testes and not other tissues (i.e., kidney and placenta) may in part explain this phenomenon and could have important implications in cancer chemotherapy.
Journal Article
Catechol-O-Methyl Transferase: Pharmacological Aspects and Physiological Role
Journal ArticleDOI
Crystal structure of catechol O-methyltransferase
TL;DR: The atomic structure of COMT is solved to 2.0 Å resolution, which provides new insights into the mechanism of the methyl transfer reaction, and the co-enzyme-binding domain is strikingly similar to that of an AdoMet-dependent DNA methylase10, indicating that all Ado met methylases may have a common structure.
Journal ArticleDOI
O-methylation of epinephrine and other catechols in vitro and in vivo.
Journal ArticleDOI
Treatment of Parkinson's disease.
TL;DR: Parkinson's disease is characterized clinically by progressive tremor, bradykinesia, and rigidity and pathologically by degeneration of the dopaminergic nigrostriatal pathway, decreases in the striatal concentration of dopamine, and the presence of laminated inclusions in neurons of the substantia nigra.
Related Papers (5)
Production of rat soluble and membrane-bound catechol O-methyltransferase forms from bifunctional mRNAs
J Tenhunen,I Ulmanen +1 more