D
Donald B. Calne
Researcher at University of British Columbia
Publications - 114
Citations - 14963
Donald B. Calne is an academic researcher from University of British Columbia. The author has contributed to research in topics: Parkinsonism & Parkinson's disease. The author has an hindex of 50, co-authored 114 publications receiving 14259 citations. Previous affiliations of Donald B. Calne include Ludwig Maximilian University of Munich & Vancouver Hospital and Health Sciences Centre.
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Journal ArticleDOI
Mutations in LRRK2 Cause Autosomal-Dominant Parkinsonism with Pleomorphic Pathology
Alexander Zimprich,Alexander Zimprich,Saskia Biskup,Petra Leitner,Peter Lichtner,Matthew J. Farrer,Sarah Lincoln,Jennifer M. Kachergus,Mary M. Hulihan,Ryan J. Uitti,Donald B. Calne,A. Jon Stoessl,Ronald F. Pfeiffer,Nadja Patenge,Iria Carballo Carbajal,Peter Vieregge,Friedrich Asmus,Bertram Müller-Myhsok,Dennis W. Dickson,Thomas Meitinger,Tim M. Strom,Zbigniew K. Wszolek,Thomas Gasser +22 more
TL;DR: High-resolution recombination mapping and candidate gene sequencing in 46 families found six disease-segregating mutations in a gene encoding a large, multifunctional protein, LRRK2 (leucine-rich repeat kinase 2), which may be central to the pathogenesis of several major neurodegenerative disorders associated with parkinsonism.
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Clinical research criteria for the diagnosis of progressive supranuclear palsy (Steele-Richardson-Olszewski syndrome) Report of the NINDS-SPSP International Workshop*
Irene Litvan,Yves Agid,Donald B. Calne,G. Campbell,Bruno Dubois,Roger C. Duvoisin,Christopher G. Goetz,Lawrence I. Golbe,Jordan Grafman,John H. Growdon,Mark Hallett,Joseph Jankovic,Niall Quinn,Eva Tolosa,David S. Zee +14 more
TL;DR: Criteria that support the diagnosis of progressive supranuclear palsy, and that exclude diseases often confused with PSP, are presented.
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In vivo positron emission tomographic evidence for compensatory changes in presynaptic dopaminergic nerve terminals in Parkinson's disease.
Chong S. Lee,Ali Samii,Vesna Sossi,Thomas J. Ruth,Michael Schulzer,James E. Holden,Jess Wudel,Pramod Kumar Pal,Raúl de la Fuente-Fernández,Donald B. Calne,A. Jon Stoessl +10 more
TL;DR: Observations suggest that the activity of aromatic L‐amino acid decarboxylase is up‐regulated, whereas the plasma membrane DA transporter is down‐regulated in the striatum of patients with PD.
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A susceptibility locus for Parkinson's disease maps to chromosome 2p13
Thomas Gasser,Bertram Müller-Myhsok,Zbigniew K. Wszolek,Ralph Oehlmann,Donald B. Calne,Vincenzo Bonifati,Benjamin Bereznai,Edito Fabrizio,Peter Vieregge,Rolf D. Horstmann +9 more
TL;DR: A different genetic locus that appears to be involved in the development of parkinsonism closely resembling sporadic PD is described including a similar mean age of onset (59 years in the families, 59.7 years in sporadic PD; ref. 12).
Journal Article
Manganese neurotoxicity: a review of clinical features, imaging and pathology.
TL;DR: Manganese intoxication can result in a syndrome of parkinsonism and dystonia that does not respond to levodopa and the primary site of neurological damage has been shown to be the globus pallidus.