Maridomycin, a new macrolide antibiotic. I. Taxonomy and fermentation.

TLDR: In this article, 4.9-Propionyl-maridomycin (PMDM) and maridomycin (MDM) were transformed into 4.4-deacyl-9-propionylmaridomycin (4.4)-propionic acid (PAA) and 4.5-probionyl maridomyscin (POMDM), respectively, by incubation with rat liver homogenates in pH 7.2 buffer solution.

Abstract: 9-Propionylmaridomycin (PMDM) and maridomycin (MDM) were transformed into 4"-deacyl-9-propionylmaridomycin (PMDM-M) and 4"-deacylmaridomycin (MDM-M), respectively, by incubation with rat liver homogenates in pH 7.2 buffer solution. The structures of these products were elucidated from their physicochemical properties and the result of chemical conversions into the known derivatives of MDM. Furthermore, PMDM-M was isolated as a main metabolite from the urine of rats treated with PMDM by oral route. On the other hand, from human urine after oral administration of PMDM, three metabolites were recovered and identified as PMDM-M, MDM and MDM-M by direct comparison.