Journal ArticleDOI
Markers of cell activation and apoptosis in bone marrow mononuclear cells of patients with autoimmune hepatitis type 1 and primary biliary cirrhosis.
Aikaterini Tsikrikoni,D. Kyriakou,Eirini I. Rigopoulou,Michael G. Alexandrakis,Kalliopi Zachou,Freda Passam,Georgios N. Dalekos +6 more
TLDR
It is demonstrated for the first time that the apoptotic process, macrophage activation and the production of cytokine suppressors of haematopoiesis in BMMCs from AIH-1 and PBC patients are higher compared to controls.About:
This article is published in Journal of Hepatology.The article was published on 2005-03-01. It has received 37 citations till now. The article focuses on the topics: Primary biliary cirrhosis & Haematopoiesis.read more
Citations
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Review article: autoimmune hepatitis -- current management and challenges.
Kalliopi Zachou,Paolo Muratori,George K. Koukoulis,Alessandro Granito,Nikolaos K. Gatselis,A. Fabbri,George N. Dalekos,Luigi Muratori +7 more
TL;DR: Autoimmune hepatitis is a disease of unknown aetiology characterised by interface hepatitis, hypergammaglobulinaemia, circulating autoantibodies and a favourable response to immunosuppression.
Journal Article
Apoptosis in liver diseases--detection and therapeutic applications.
TL;DR: This review outlines the recent findings that highlight the role and mechanisms of apoptotic processes in the course of liver diseases, and discusses the role of tumor necrosis factor, HBx, ds-PKR, TRAIL, FasL, and IL-1alpha in hepatocyte apoptosis.
Journal ArticleDOI
Genetic Factors Affecting the Occurrence, Clinical Phenotype, and Outcome of Autoimmune Hepatitis
TL;DR: Knowledge of the genetic predispositions for autoimmune hepatitis may elucidate pathogenic mechanisms, identify etiologic agents, characterize susceptible populations, foresee outcomes, and target new therapies.
Journal ArticleDOI
Current and future treatments of autoimmune hepatitis.
TL;DR: Patients with autoimmune hepatitis should be considered for Liver transplantation in patients with hepatic failure unresponsive to corticosteroid treatment, decompensated cirrhosis with a Model for End-Stage Liver Disease score of at least 15 points, or hepatocellular carcinoma that meets transplantation criteria.
Journal ArticleDOI
Comparison of simplified score with the revised original score for the diagnosis of autoimmune hepatitis: A new or a complementary diagnostic score?
Nikolaos K. Gatselis,Kalliopi Zachou,Panagiotis Papamichalis,George K. Koukoulis,Stella Gabeta,George N. Dalekos,Eirini I. Rigopoulou +6 more
TL;DR: The simplified score is a reliable and simple tool for excluding autoimmune hepatitis, however, both systems cannot unmask autoimmune hepatitis component efficiently in autoimmune hepatitis patients with concurrent autoimmune or non-autoimmune liver diseases.
References
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Journal ArticleDOI
The Fas Death Factor
Shigekazu Nagata,Pierre Golstein +1 more
TL;DR: Fas ligand (FasL), a cell surface molecule belonging to the tumor necrosis factor family, binds to its receptor Fas, thus inducing apoptosis of Fas-bearing cells.
Journal ArticleDOI
International Autoimmune Hepatitis Group Report: review of criteria for diagnosis of autoimmune hepatitis
Fernando Alvarez,P.A. Berg,Francesco B. Bianchi,Leonardo Bianchi,A.K. Burroughs,Eduardo Luiz Rachid Cançado,Roger W. Chapman,W. G. E. Cooksley,Albert J. Czaja,V J Desmet,Peter T. Donaldson,A. L. W. F. Eddleston,L. Fainboim,Jenny Heathcote,Jean-Claude Homberg,Jay H. Hoofnagle,Shinichi Kakumu,Edward L. Krawitt,Ian R. Mackay,R. N. M. Macsween,Willis C. Maddrey,Michael P. Manns,I.G. McFarlane,K H Meyer zum Büschenfelde,G. Mieli-Vergani,Yasuni Nakanuma,Mikio Nishioka,Edward Penner,Gilda Porta,Bernard Portmann,W. D. Reed,Joan Rodés,Solko W. Schalm,P. J. Scheuer,Erik Schrumpf,Takeshi Seki,Gotaro Toda,Takao Tsuji,Niels Tygstrup,Diego Vergani,Mikio Zeniya +40 more
Journal ArticleDOI
Fas Ligand-Induced Apoptosis as a Mechanism of Immune Privilege
TL;DR: Inflammatory cells entering the anterior chamber of the eye in response to viral infection underwent apoptosis that was dependent on Fas (CD95)-Fas ligand (FasL) and produced no tissue damage.
Journal ArticleDOI
Fas and Fas ligand: lpr and gld mutations
Shigekazu Nagata,Takashi Suda +1 more
TL;DR: The physiological role of the Fas system in T-cell development, cytotoxicity and cytotoxic T lymphocyte (CTL)-mediated autoimmune disease is discussed and current knowledge of Fas and FasL is summarized.
Journal Article
Differential expression of apoptosis-related Fas antigen on lymphocyte subpopulations in human peripheral blood.
Toshio Miyawaki,Takahiro Uehara,Ryutaro Nibu,Takao Tsuji,Akihiro Yachie,Shin Yonehara,Noboru Taniguchi +6 more
TL;DR: In contrast to Fas-expressing cultured cell lines, viability of in vitro stimulated T and B cells as well as freshly isolated CD45RO+ T cells was not significantly changed after the treatment with anti-Fas mAb, indicating that additional cellular conditions to Fas expression might be required for anti-fas-induced cell death.
Related Papers (5)
International Autoimmune Hepatitis Group Report: review of criteria for diagnosis of autoimmune hepatitis
Fernando Alvarez,P.A. Berg,Francesco B. Bianchi,Leonardo Bianchi,A.K. Burroughs,Eduardo Luiz Rachid Cançado,Roger W. Chapman,W. G. E. Cooksley,Albert J. Czaja,V J Desmet,Peter T. Donaldson,A. L. W. F. Eddleston,L. Fainboim,Jenny Heathcote,Jean-Claude Homberg,Jay H. Hoofnagle,Shinichi Kakumu,Edward L. Krawitt,Ian R. Mackay,R. N. M. Macsween,Willis C. Maddrey,Michael P. Manns,I.G. McFarlane,K H Meyer zum Büschenfelde,G. Mieli-Vergani,Yasuni Nakanuma,Mikio Nishioka,Edward Penner,Gilda Porta,Bernard Portmann,W. D. Reed,Joan Rodés,Solko W. Schalm,P. J. Scheuer,Erik Schrumpf,Takeshi Seki,Gotaro Toda,Takao Tsuji,Niels Tygstrup,Diego Vergani,Mikio Zeniya +40 more