Open AccessJournal Article
[Mechanisms of the early effect of biologically active hydroxysterols: calcitriol and ecdysterone. Modulation of intracellular pools of arachidonic acid and products of its oxidative metabolism].
TLDR
In this paper, it was established that ecdysterone (20-hydroxyecdysone) in concentration of 10(-8) M and calcitriol (1 alpha, 25-dihydroxyvitamin D3) evoke in the studied tissues-targets of rats (brain, heart, liver, intestine mucosa) rapid (0.5-2 min) transit (2.5 -4 times) increase of the intracellular pools of arachidonic acid, eicosanoid, total peptidoleukotrienAbstract:
It is established that ecdysterone (20-hydroxyecdysone) in concentration of 10(-8) M and calcitriol (1 alpha, 25-dihydroxyvitamin D3) in concentration 10(-12) M evoke in the studied tissues-targets of rats (brain, heart, liver, intestine mucosa) rapid (0.5-2 min) transit (2.5-4 times) increase of the intracellular pools of arachidonic acid, eicosanoid--total peptidoleukotrienes C4/D4/E4 (2.5-6 times), and, especially prostaglandins--stable metabolite prostacyclin 6-ketoprostaglandin F1 alpha (10-400 times). Ecdysterone in concentration 10(-11)-10(-9) inhibits arachidonic cascade in the brain and heart. Activation of arachidonic cascade and further increase of biosynthesis of cGMP are considered as a single negative link of autoregulation of activity of phospholipid-dependent signal system of cells and ecdysterone as a possible efficient modulator intracellular pools of eicosanoid in the tissues of warm-blooded animals.read more
Citations
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Journal ArticleDOI
Practical uses for ecdysteroids in mammals including humans: an update
René Lafont,Laurie Dinan +1 more
TL;DR: These systems, which are currently mainly used in vitro with cultured cells in order to analyse the role of a wide array of genes, but which are expected to represent the basis for future gene therapy strategies are reviewed.
Journal ArticleDOI
Effects and applications of arthropod steroid hormones (ecdysteroids) in mammals.
Laurence Dinan,René Lafont +1 more
TL;DR: Findings on the occurrence, metabolism and pharmacological effects of ecdysteroids in mammalian systems are summarized and their potential applications are drawn attention, particularly in gene-switch technology, where Ecdysteroid analogues can be used as effective and potent elicitors.
Posted ContentDOI
20-Hydroxyecdysone activates the protective arm of the renin angiotensin system via Mas receptor
Rencé Lafont,Sophie Raynal,Maria Serova,Blaise Didry-Barca,Louis Guibout,Mathilde Latil,Pierre J. Dilda,Waly Dioh,Stanislas Veillet +8 more
TL;DR: The possibility to activate the Mas receptor with a safe steroid molecule is consistent with the pleiotropic pharmacological effects of ecdysteroids in mammals and indeed this mechanism may explain the close similarity between angiotensin-(1-7) and 20E effects.
Dissertation
Effets d'un extrait de quinoa enrichi en 20-hydroxyecdysone dans un modèle d'obésité nutritionnelle : application clinique
TL;DR: In this paper, the authors present an apport alimentaire d'extrait de quinoa enrichi en 20-hydroxyecdysone chez la souris soumise a un regime hyperlipidique a permis de limiter le developpement du tissu adipeux, without modifier la prise alimentaires.
References
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Journal ArticleDOI
Practical uses for ecdysteroids in mammals including humans: an update
René Lafont,Laurie Dinan +1 more
TL;DR: These systems, which are currently mainly used in vitro with cultured cells in order to analyse the role of a wide array of genes, but which are expected to represent the basis for future gene therapy strategies are reviewed.
Journal ArticleDOI
Effects and applications of arthropod steroid hormones (ecdysteroids) in mammals.
Laurence Dinan,René Lafont +1 more
TL;DR: Findings on the occurrence, metabolism and pharmacological effects of ecdysteroids in mammalian systems are summarized and their potential applications are drawn attention, particularly in gene-switch technology, where Ecdysteroid analogues can be used as effective and potent elicitors.
Posted ContentDOI
20-Hydroxyecdysone activates the protective arm of the renin angiotensin system via Mas receptor
Rencé Lafont,Sophie Raynal,Maria Serova,Blaise Didry-Barca,Louis Guibout,Mathilde Latil,Pierre J. Dilda,Waly Dioh,Stanislas Veillet +8 more
TL;DR: The possibility to activate the Mas receptor with a safe steroid molecule is consistent with the pleiotropic pharmacological effects of ecdysteroids in mammals and indeed this mechanism may explain the close similarity between angiotensin-(1-7) and 20E effects.
Dissertation
Effets d'un extrait de quinoa enrichi en 20-hydroxyecdysone dans un modèle d'obésité nutritionnelle : application clinique
TL;DR: In this paper, the authors present an apport alimentaire d'extrait de quinoa enrichi en 20-hydroxyecdysone chez la souris soumise a un regime hyperlipidique a permis de limiter le developpement du tissu adipeux, without modifier la prise alimentaires.