Open AccessJournal Article
Membrane polypeptide aggregates in glucose 6-phosphate dehydrogenase-deficient and in vitro aged red blood cells.
TLDR
RBC membrane polypeptide aggregates have been quantitated by PAGE SDS and by gel filtration and may represent an early and sensitive indicator of oxidative damage to red cells.About:
This article is published in Journal of Laboratory and Clinical Medicine.The article was published on 1978-02-01 and is currently open access. It has received 40 citations till now. The article focuses on the topics: Dithiothreitol.read more
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Oxidant damage mediates variant red cell resistance to malaria
TL;DR: Evidence is presented here that both α- and β-thal trait red cells from adults are refractory to parasite development because of oxidant sensitivity, and, furthermore, that fetal red cells and G6PD− cells areRefractory for the same reason.
Journal ArticleDOI
Glutathione cycle activity and pyridine nucleotide levels in oxidant-induced injury of cells.
Ingrid U. Schraufstatter,Daniel B. Hinshaw,Paul A. Hyslop,Roger G. Spragg,Charles G. Cochrane +4 more
TL;DR: Early metabolic events take place that are important in the fate of the cell exposed to oxidants that are described in P388D1 macrophagelike tumor cells: activation of the glutathione cycle and depletion of cellular NAD.
Journal ArticleDOI
Oxidant damage of the lipids and proteins of the erythrocyte membranes in unstable hemoglobin disease. Evidence for the role of lipid peroxidation.
TL;DR: The erythrocyte membranes in hemoglobin Köln disease show evidence of lipid peroxidation with production of malonyldialdehyde, and it is concluded that the nondissociable membrane aggregates formed in this disease are likely cross-linked by maloneyldial dehyde.
Journal ArticleDOI
Red-cell-membrane polypeptide aggregates in glucose-6-phosphate dehydrogenase mutants with chronic hemolytic disease. A clue to the mechanism of hemolysis.
Gerhard J. Johnson,David W. Allen,Shirley Cadman,Virgil F. Fairbanks,James G. White,Beatrice C. Lampkin,Manuel E. Kaplan +6 more
TL;DR: Red-cell membranes from patients with glucose-6-phosphate dehydrogenase deficiency were studied and it is postulate that the polypeptide aggregates are indicators of oxidant damage to the red-cell membrane, which results in decreased deformability and chronic hemolysis.