Journal ArticleDOI
Metabolism of dextrosulphenidol in several animal species
Reads0
Chats0
TLDR
The in vivo metabolism of dextrosulphenidol has been studied using various test organisms and comparisons are made as to the effect of biological variation on the absorption, distribution, and excretion of the drug.Abstract:
The in vivo metabolism of dextrosulphenidol has been studied using various test organisms. Differences are noted and comparisons are made as to the effect of biological variation on the absorption, distribution, and excretion of the drug.read more
Citations
More filters
Journal ArticleDOI
Pharmacokinetics of florfenicol in veal calves
TL;DR: Calves given the oral doses had a complex absorption pattern with delayed absorption and slightly more than 50% of the administered dose both orally and intravenously was recovered as unchanged florfenicol in the urine by 30 h.
Journal ArticleDOI
Chloramphenicol metabolism in the phenobarbital-induced rat. Comparison with thiamphenicol.
TL;DR: Blood levels and chemotherapeutic activity of chloramphenicol were distinctly reduced by pretreatment with phenobarbital, and urinary excretion was enhanced; the latter was entirely accounted for by an increase in the glucuronide fraction.
Journal ArticleDOI
Embryonic development and mitochondrial function. 1. Effects of chloramphenicol infusion on the synthesis of cytochrome oxidase and DNA in rat embryos during late organogenesis.
Detlef Oerter,Rolf Bass +1 more
TL;DR: The extent of inhibition of DNA synthesis provoked by inhibition of mitochondrial protein synthesis depends on a number of factors which include: different growth rates during organogenesis, the number of mitochondria present prior to treatment, availability of extramitochondrial ATP sources and placental permeability barrier.
Journal ArticleDOI
Allometric analysis of thiamphenicol disposition among seven mammalian species
TL;DR: The comparison between experimental and extrapolated values suggests that it could be possible to extrapolate, with good prediction, the kinetic parameters of this drug for mammalian species, using allometric scaling, except for the species that eliminate the drug by a combination of renal excretion and hepatic metabolism.
Journal ArticleDOI
Embryonic development and mitochondrial function. 2. Thiamphenicol induced embryotoxicity.
Rolf Bass,Detlef Oerter +1 more
TL;DR: In this article, the effect of mitochondrial protein synthesis in rat embryos during late organogenesis leads to impaired embryonic development, and the extent of inhibition of DNA synthesis provoked by inhibition of mitochondria is investigated.
References
More filters
Journal ArticleDOI
Biochemical studies on chloramphenicol (chloromycetin) iii. isolation and identification of metabolic products in urine
TL;DR: The present communication is concerned with the isolation and identification of chloramphenicol and its metabolic products from urine, chromatographic and counter-current methods for separation being used.
Journal Article
Biochemical studies on chloramphenicol; tissue distribution and excretion studies.
Glazko Aj,Wolf Lm +1 more
TL;DR: In the rat, parenteral administration of chioramphenicol results in excretion into the intestine by way of the bile, principally as inactive nitro compounds that may be partly reabsorbed, or reduced in the intestine to form aryl amines which are excreted in the feces.
Journal Article
The chemical determination of chloramphenicol in biological materials.
Levine J,Fischbach H +1 more
Journal ArticleDOI
Administration of chloromycetin to normal human subjects.
TL;DR: The presence of appreciable amounts of drug in the blood and urine of volunteers 30 minutes after oral administration of Chloromycetin indicates that the antibiotic is absorbed rapidly from the gastrointestinal tract of man.
Journal Article
Observations on the metabolic disposition of chloramphenicol (chloromycetin) in the rat.
TL;DR: In the caecum and large intestine of the rat the glucuronide is readily hydrolyzed by bacterial action, and large quantities of aromatic amines are formed by reduction of the nitro group.
Related Papers (5)
A rapid gas chromatographic method for the determination of thiamphenicol in body fluids and tissues.
A dog is not a rat: importance of understanding species differences in drug absorption, distribution, metabolism and excretion (ADME).
Rahul Deshmukh,Eric A.G. Blomme +1 more