M
Marek T. Cegla
Researcher at Jagiellonian University Medical College
Publications - 59
Citations - 798
Marek T. Cegla is an academic researcher from Jagiellonian University Medical College. The author has contributed to research in topics: Aniline & Aryl. The author has an hindex of 16, co-authored 57 publications receiving 748 citations. Previous affiliations of Marek T. Cegla include Jagiellonian University & Georgia State University.
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Journal ArticleDOI
Synthesis and quantitative structure-activity relationship analysis of 2-(aryl or heteroaryl)quinolin-4-amines, a new class of anti-hiv-1 agents
Lucjan Strekowski,J. L. Mokrosz,Vidya A. Honkan,Agnieszka Czarny,Marek T. Cegla,Roman L. Wydra,Steven E. Patterson,Raymond F. Schinazi +7 more
TL;DR: The results of the quantitative structure-activity relationship analyses, including several classical, linear regression correlations and a Free-Wilson approach of de novo model, provide guidelines for the design of new active compounds of this class.
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Structure-activity relationship studies of central nervous system agents. 5. Effect of the hydrocarbon chain on the affinity of 4-substituted 1-(3-chlorophenyl)piperazines for 5-HT1A receptor site.
TL;DR: It was shown that hydrophobic interactions of N-4 substituents of 1-arylpiperazines significantly contribute to their 5-HT1A affinity, and the range of Ki(AH+) = 1 - 3 x 10(-11) M is a specific affinity limit of the investigated class of compounds at the 5- HT1A receptor sites.
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Further Studies on the Cyclization of Aromatic Azomethines Ortho-Substituted with a Trifluoromethyl Group: Synthesis of 2,4-Di-or 2,3,4-Trisubstituted Quinolines
Lucjan Strekowski,Steven E. Patterson,Lubomir Janda,Roman L. Wydra,Donald B. Harden,Malgorzata Lipowska,Marek T. Cegla +6 more
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An unusual base-mediated cyclization of ketimines derived from 2-(trifluoromethyl)aniline that involves the trifluoromethyl group: an expedient route to 2-arylquinolines
Lucjan Strekowski,Roman L. Wydra,Marek T. Cegla,Agnieszka Czarny,Donald B. Harden,Steven E. Patterson,Merle A. Battiste,James M. Coxon +7 more
TL;DR: In this article, trifluoromethyl-substituted ketimines with strong bases are suggested intermediates in a novel synthetic route to 2-arylquinolines.
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Preliminary evaluation of pharmacological properties of some xanthone derivatives
Henryk Marona,Natalia Szkaradek,Anna Rapacz,Barbara Filipek,Małgorzata Dybała,Agata Siwek,Marek T. Cegla,Edward Szneler +7 more
TL;DR: The data obtained via receptor binding assay are in agreement with pharmacological results and could explain antiarrhythmic and/or hypotensive activity of the newly synthesized structures.