Patent
Methods of screening compounds for grk6 modulating activity
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In this article, the authors proposed methods of treating disease by altering G protein coupled receptor kinase (GRK) 6, which may be done by altering the expression or activity of the protein, for example.Abstract:
The present invention relates to methods of treating disease by altering G protein coupled receptor kinase (GRK) 6. This may be done by altering the expression or activity of the protein, for example. The present invention may be used for disease diagnosis, by detecting the expression or activity of GRK6. The present invention relates to a GRK6 deficient mouse, GRK6 splice variants, and methods of use. The present invention also relates to methods of identifying compounds that alter GRK6 activity. The present invention relates to disease treatment by altering GRK6 expression or activity.read more
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References
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Patent
Modified green fluorescent proteins
Roger Y. Tsien,Roger Heim +1 more
TL;DR: In this paper, modifications in the sequence of Aequorea wild-type GFP provide products having markedly different excitation and emission spectra from corresponding products from wild type GFP.
Journal ArticleDOI
Defective lymphocyte chemotaxis in β-arrestin2- and GRK6-deficient mice
Alan M. Fong,Richard T. Premont,Ricardo M. Richardson,Yen-Rei A. Yu,Robert J. Lefkowitz,Dhavalkumar D. Patel +5 more
TL;DR: Results indicate that β-arrestin2 and GRK6 actually play positive regulatory roles in mediating the chemotactic responses of T and B lymphocytes to CXCL12.
Patent
Methods of assaying receptor activity and constructs useful in such methods
TL;DR: In this article, methods of detecting G-protein coupled receptor (GPCR) activity in vivo and in vitro, and methods of assaying GPCR activity were described.
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Improved systems for sensitive detection of g-protein coupled receptor and orphan receptor function using reporter enzyme mutant complementation
TL;DR: In this paper, a G-protein coupled receptor (GPCR) signal activation was detected by employing a GPCR fusion protein comprising an inactive form of an enzyme and an interacting protein partner fusion protein.
Patent
G protein-coupled receptor kinase GRK6
TL;DR: In this paper, the authors provided purified and isolated polynucleotide sequences encoding the novel G protein-coupled receptor kinase designated GRK6, and provided methods and materials for the recombinant production of GRK 6 enzyme and methods for identifying compounds which modulate the protein kinase activity.