R
Raul R. Gainetdinov
Researcher at Saint Petersburg State University
Publications - 338
Citations - 34136
Raul R. Gainetdinov is an academic researcher from Saint Petersburg State University. The author has contributed to research in topics: Dopamine & Dopaminergic. The author has an hindex of 80, co-authored 303 publications receiving 30663 citations. Previous affiliations of Raul R. Gainetdinov include Academy of Medical Sciences, United Kingdom & University of North Carolina at Chapel Hill.
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The Physiology, Signaling, and Pharmacology of Dopamine Receptors
TL;DR: D dopamine receptor classification, their basic structural and genetic organization, their distribution and functions in the brain and the periphery, and their regulation and signal transduction mechanisms are discussed.
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Mice with Reduced NMDA Receptor Expression Display Behaviors Related to Schizophrenia
TL;DR: The generation of mice expressing only 5% of normal levels of the essential NMDAR1 (NR1) subunit is reported, supporting a model in which reduced NMDA receptor activity results in schizophrenic-like behavior and reveals how pharmacological manipulation of monoaminergic pathways can affect this phenotype.
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Enhanced Morphine Analgesia in Mice Lacking β-Arrestin 2
Laura M. Bohn,Robert J. Lefkowitz,Raul R. Gainetdinov,Karsten Peppel,Marc G. Caron,Fang-Tsyr Lin +5 more
TL;DR: It is suggested that inhibition of beta-arrestin 2 function might lead to enhanced analgesic effectiveness of morphine and provide potential new avenues for the study and treatment of pain, narcotic tolerance, and dependence.
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Direct generation of functional dopaminergic neurons from mouse and human fibroblasts
Massimiliano Caiazzo,Maria Teresa Dell’Anno,Elena Dvoretskova,Dejan Lazarevic,Dejan Lazarevic,Stefano Taverna,Damiana Leo,Tatyana D. Sotnikova,Andrea Menegon,Paola Roncaglia,Giorgia Colciago,Giovanni Russo,Piero Carninci,Gianni Pezzoli,Raul R. Gainetdinov,Stefano Gustincich,Stefano Gustincich,Alexander Dityatev,Vania Broccoli +18 more
TL;DR: A minimal set of three transcription factors were able to elicit dopaminergic neuronal conversion in prenatal and adult fibroblasts from healthy donors and Parkinson’s disease patients and might have significant implications for understanding critical processes for neuronal development, in vitro disease modelling and cell replacement therapies.
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An Akt/β-Arrestin 2/PP2A Signaling Complex Mediates Dopaminergic Neurotransmission and Behavior
Jean-Martin Beaulieu,Tatyana D. Sotnikova,Sébastien Marion,Robert J. Lefkowitz,Raul R. Gainetdinov,Marc G. Caron +5 more
TL;DR: It is demonstrated that, apart from its classical function in receptor desensitization, beta-arrestin 2 also acts as a signaling intermediate through a kinase/phosphatase scaffold, thus implicating beta-arsenin 2 as a positive mediator of dopaminergic synaptic transmission and a potential pharmacological target for dopamine-related psychiatric disorders.