Book ChapterDOI
Microfluidic Filtration Chip for DNA Extraction and Concentration
Agata Przekwas,DeMing Wang,Vinod Makhijani,Andrzej Przekwas +3 more
- pp 488-497
TLDR
Multi-disciplinary computational tool, CFD-ACE+MEMS, for simulation and design of microfluidic bioMEMS is presented and demonstrated on 3D high-fidelity simulations in microfluidity channels and on a complex DNA filtration chip.Abstract:
In the last few years there has been tremendous interest in developing a complete biomedical/biochemical intelligent microsystem for extraction, concentration, amplification, analysis and processing of DNA. This paper presents multi-disciplinary computational tool, CFD-ACE+MEMS, for simulation and design of microfluidic bioMEMS. It is demonstrated on 3D high-fidelity simulations in microfluidic channels and on a complex DNA filtration chip.read more
Citations
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Journal ArticleDOI
AC electroosmotic flow in a DNA concentrator
M. R. Bown,Carl D. Meinhart +1 more
TL;DR: In this article, experimental velocity measurements are conducted in an AC electrokinetic DNA concentrator, which consists of two concentric electrodes that generate AC electroosmotic flow to stir the fluid, and dielectrophoretic and electric force fields that trap DNA near the center of the inside electrode.
Proceedings ArticleDOI
Measurement and Modeling of MEMS
TL;DR: In this paper, the authors combine a unique, fully integrated, software environment for multiscale, multiphysics, high fidelity analyses of MEMS with the SOTA optoelectronic laser interferometric microscope (OELIM) methodology.
Proceedings ArticleDOI
Modeling and measurements of MEMS gyroscopes
TL;DR: In this article, the authors combine a unique, fully integrated, software environment for multiscale, multiphysics, high fidelity analyses of MEMS gyroscopes with the SOTA optoelectronic laser interferometric microscope (OELIM) methodology.
Book ChapterDOI
Computational pharmacokinetic modeling of organ-on-chip devices and microphysiological systems
TL;DR: This chapter reviews recent achievements and identifies new directions for application of multiscale computational methods in OoC research.
ReportDOI
Mixed-Dimensionality VLSI-Type Configurable Tools for Virtual Prototyping of Biomicrofluidic Devices and Integrated Systems
Vinod Makhijani,Andrzej Przekwas +1 more
TL;DR: The CFD-ACE+Multiphysics project as discussed by the authors was a three-year team effort between CFD Research Corporation, California Institute of Technology (CalTech), University of California, Berkeley (UCB), and Tanner Research, with Mr. Don Verlee from Abbott Labs participating as a consultant on the project.
References
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Journal ArticleDOI
Functional integration of PCR amplification and capillary electrophoresis in a microfabricated DNA analysis device.
Adam T. Woolley,Dean R. Hadley,Phoebe Landre,Andrew J. deMello,Richard A. Mathies,Northrup Ma +5 more
TL;DR: The feasibility of performing high-speed DNA analyses in microfabricated integrated fluidic systems is established, demonstrating that challenging amplifications of diagnostically interesting targets can also be performed.
Journal ArticleDOI
DNA probes: applications of the principles of nucleic acid hybridization.
TL;DR: In this article, the authors discuss the thermodynamics and kinetics of nucleic acid hybridization with a labeled probe, which is the only practical way to detect a complementary target sequence.
Journal ArticleDOI
Ultra-high-speed DNA sequencing using capillary electrophoresis chips.
TL;DR: The feasibility of high-speed, high-throughput DNA sequencing using capillary array electrophoresis chips is established and the prospects for enhancing the resolution and sensitivity of these chip separations are discussed.
Journal ArticleDOI
Microchip Capillary Electrophoresis with an Integrated Postcolumn Reactor
TL;DR: A glass microchip with a postcolumn reactor was fabricated to conduct postseparation derivatization using o-phthaldialdehyde as a fluorescent "tag" for amino acids as mentioned in this paper.
Journal ArticleDOI
A miniature analytical instrument for nucleic acids based on micromachined silicon reaction chambers
Northrup Ma,B Benett,Dean R. Hadley,Phoebe Landre,Stacy L. Lehew,James B. Richards,Paul Stratton +6 more
TL;DR: The MATCI is an integrated, miniaturized analytical system that uses silicon-based, high-efficiency reaction chambers with integrated heaters and simple, inexpensive electronics to precisely control the reaction temperatures.