Journal ArticleDOI
Milk Thistle ( Silybum marianum ) for the Therapy of Liver Disease
TLDR
Silymarin and its active constituent, silybin, have been reported to work as antioxidants scavenging free radicals and inhibiting lipid peroxidation, and to protect against genomic injury and stabilize mast cells, chelate iron, and slow calcium metabolism.About:
This article is published in The American Journal of Gastroenterology.The article was published on 1998-02-01. It has received 709 citations till now. The article focuses on the topics: Milk Thistle & Silybum marianum.read more
Citations
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Journal ArticleDOI
The Use of Silymarin in the Treatment of Liver Diseases
TL;DR: It is concluded that available evidence suggests that silymarin may play a role in the therapy of (alcoholic) liver cirrhosis and has a good safety record and only rare case reports of gastrointestinal disturbances and allergic skin rashes have been published.
Journal Article
Hepatoprotective herbal drug, silymarin from experimental pharmacology to clinical medicine.
Suresh Chandra Pradhan,C Girish +1 more
TL;DR: Silymarin may prove to be a useful drug for hepatoprotection in hepatobiliary diseases and in hepatotoxicity due to drugs, as it is having a good safety profile, better patient tolerability and an effective drug at an affordable price.
Journal ArticleDOI
Oxidative stress in viral and alcoholic hepatitis
TL;DR: By enhancing the antioxidant ability of hepatocytes, through transgene vectors, one could counteract oxidative/nitrosative stress and, in this way, contribute to blocking the progression of liver disease.
Journal ArticleDOI
Silymarin: a review of its clinical properties in the management of hepatic disorders
Keri Wellington,Blair Jarvis +1 more
TL;DR: Although silymarin has low oral absorption, oral dosages of 420 mg/day have shown some therapeutic potential, with good tolerability, in the treatment of alcoholic cirrhosis, and the antioxidant properties of sily marin have been demonstrated in vitro and in animal and human studies.
Journal ArticleDOI
Silybin and silymarin - new effects and applications
Vladimir Kren,Daniela Walterová +1 more
TL;DR: This article aims to review critically literature published mainly within this millennium on the new and emerging applications of silymarin, the polyphenolic fraction from the seeds of Silybum marianum and its main component silybin, to suggest new mechanisms of its action.
References
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Journal ArticleDOI
Randomized controlled trial of silymarin treatment in patients with cirrhosis of the liver.
Peter Ferenci,Brigitte Dragosics,H. Dittrich,H. Frank,L. Benda,H. Lochs,Siegfried Meryn,W. Base,B. Schneider +8 more
TL;DR: Analysis of subgroups indicated that treatment was effective in patients with alcoholic cirrhosis and in patients initially rated 'Child A' (P = 0.01) and in customers initially rated "Child A" (P= 0.03).
Book
New Natural Products and Plant Drugs with Pharmacological, Biological or Therapeutical Activity
H. Wagner,P. Wolff +1 more
TL;DR: GACP-Quality control methods for crude drugs to Illuminate the importance of herbs/plants for therapeutic purpose and develop new techniques in plant tissue cultures, Nutraceuticals.
Journal ArticleDOI
Pharmacokinetic studies on IdB 1016, a silybin-phosphatidylcholine complex, in healthy human subjects
TL;DR: It is concluded that complexation with phosphatidylcholine in IdB 1016 greatly increases the oral bioavailability of silybin, probably by facilitating its passage across the gastrointestinal mucosa.
Journal ArticleDOI
Scavenging of reactive oxygen species by silibinin dihemisuccinate
TL;DR: In this article, the antioxidant properties of Silibinin dihemisuccinate (SDH) were evaluated by studying the ability of this drug to react with relevant biological oxidants such as Superoxide anion radical (O ⨪ 2 ), hydrogen peroxide (H 2 O 2 ), hydroxyl radical (HO. ) and hypochlorous acid (HOCl).
Related Papers (5)
The Use of Silymarin in the Treatment of Liver Diseases
Silymarin: a review of its clinical properties in the management of hepatic disorders
Keri Wellington,Blair Jarvis +1 more