Journal ArticleDOI
Scavenging of reactive oxygen species by silibinin dihemisuccinate
TLDR
In this article, the antioxidant properties of Silibinin dihemisuccinate (SDH) were evaluated by studying the ability of this drug to react with relevant biological oxidants such as Superoxide anion radical (O ⨪ 2 ), hydrogen peroxide (H 2 O 2 ), hydroxyl radical (HO. ) and hypochlorous acid (HOCl).About:
This article is published in Biochemical Pharmacology.The article was published on 1994-08-17. It has received 191 citations till now. The article focuses on the topics: Lipid peroxidation & Reactive oxygen species.read more
Citations
More filters
Journal ArticleDOI
Interactions of Flavonoids with Iron and Copper Ions: A Mechanism for their Antioxidant Activity
Lurdes Mira,M T Fernandez,Marta R. Santos,Rafaella Martins Freitas Rocha,M. H. Florêncio,Keith R. Jennings +5 more
TL;DR: The metal chelating properties of flavonoids suggest that they may play a role in metal-overload diseases and in all oxidative stress conditions involving a transition metal ion.
Journal ArticleDOI
Milk Thistle ( Silybum marianum ) for the Therapy of Liver Disease
TL;DR: Silymarin and its active constituent, silybin, have been reported to work as antioxidants scavenging free radicals and inhibiting lipid peroxidation, and to protect against genomic injury and stabilize mast cells, chelate iron, and slow calcium metabolism.
Journal ArticleDOI
The Use of Silymarin in the Treatment of Liver Diseases
TL;DR: It is concluded that available evidence suggests that silymarin may play a role in the therapy of (alcoholic) liver cirrhosis and has a good safety record and only rare case reports of gastrointestinal disturbances and allergic skin rashes have been published.
Journal ArticleDOI
Cutaneous photodamage, oxidative stress, and topical antioxidant protection
TL;DR: This scientific review summarizes what is known about how photodamage occurs; why sunscreens--the current gold standard of photoprotection--are inadequate; and how topical AOs help protect against skin cancer and photoaging changes.
Journal ArticleDOI
Thymoquinone is a potent superoxide anion scavenger
TL;DR: The results suggest that both TQ and TBHQ have strong antioxidant potentials through scavenging ability of different free radicals, and indicate that TQ is acting mainly as a potent superoxide anion scavenger.
References
More filters
Journal Article
Protein Measurement with the Folin Phenol Reagent
TL;DR: Procedures are described for measuring protein in solution or after precipitation with acids or other agents, and for the determination of as little as 0.2 gamma of protein.
Journal ArticleDOI
The Role of Superoxide Anion in the Autoxidation of Epinephrine and a Simple Assay for Superoxide Dismutase
Hara P. Misra,Irwin Fridovich +1 more
TL;DR: It is proposed that the autoxidation of epinephrine proceeds by at least two distinct pathways, only one of which is a free radical chain reaction involving O2- and hence inhibitable by superoxide dismutase.
Journal Article
Biology of disease: free radicals and tissue injury.
Bruce A. Freeman,James D. Crapo +1 more
TL;DR: This review surveys cellular sources of free radicals and the reactions they can undergo and discusses cellular defenses and adaptive mechanisms.
Journal ArticleDOI
The deoxyribose method: a simple "test-tube" assay for determination of rate constants for reactions of hydroxyl radicals.
TL;DR: It is suggested that the deoxyribose assay is a simple and cheap alternative to pulse radiolysis for determination of rate constants for reaction of most biological molecules with hydroxyl radicals.
Book ChapterDOI
Flavonoids as antioxidants: determination of radical-scavenging efficiencies.
TL;DR: The radical chemistry of flavonoids not only is of interest from a kinetic or mechanistic point of view but also offers considerable insight into structural relationships of highly evolved plant components.
Related Papers (5)
The Use of Silymarin in the Treatment of Liver Diseases
Inhibition of Kupffer cell functions as an explanation for the hepatoprotective properties of silibinin
C Dehmlow,J. Erhard,H de Groot +2 more