Journal ArticleDOI
Moderate running exercise augments glycosaminoglycans and thickness of articular cartilage in the knee joint of young beagle dogs.
TLDR
It is considered that moderate running exercise locally alters the biological properties of young articular cartilage at regions bearing the highest loading surplus.About:
This article is published in Journal of Orthopaedic Research.The article was published on 1988-03-01. It has received 307 citations till now. The article focuses on the topics: Osteoarthritis & Femur.read more
Citations
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Journal ArticleDOI
Biosynthetic response of cartilage explants to dynamic compression.
TL;DR: This study provides a framework for identifying both the physical and biological mechanisms by which dynamic compression can modulate chondrocyte biosynthesis and potentially allows in vitro evaluation of clinical strategies of continuous passive motion therapy to stimulate cartilage remodeling.
Journal ArticleDOI
Mechanical compression modulates matrix biosynthesis in chondrocyte/agarose culture
TL;DR: In this article, the effect of static and dynamic mechanical compression on the biosynthetic activity of chondrocytes cultured within agarose gel was studied, and it was shown that the presence or absence of matrix, as well as the physical properties of the disks, suggested that cell-matrix interactions (e.g. mechanical and/or receptor mediated) and extracellular physicochemical effects (increased [Na+], reduced pH) may be more important than matrix-independent cell deformation and transport limitations in determining the response to static compression.
Journal ArticleDOI
Knee osteoarthritis has doubled in prevalence since the mid-20th century
Ian J. Wallace,Steven Worthington,David T. Felson,Robert Jurmain,Kimberly T. Wren,Heli Maijanen,Robert J. Woods,Daniel E. Lieberman +7 more
TL;DR: It is shown that knee OA long existed at low frequencies, but since the mid-20th century, the disease has doubled in prevalence, contradict the view that the recent surge in knee osteoarthritis occurred simply because people live longer and are more commonly obese.
Journal ArticleDOI
Compressive strains at physiological frequencies influence the metabolism of chondrocytes seeded in agarose.
David A. Lee,Dan L. Bader +1 more
TL;DR: The three parameters investigated were each influenced by the dynamic strain regimens in a distinct manner, implying that the signalling mechanisms involved are uncoupled.
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Risk of osteoarthritis associated with long-term weight-bearing sports: a radiologic survey of the hips and knees in female ex-athletes and population controls.
Tim D. Spector,Pat A. Harris,Deborah J. Hart,Flavia M. Cicuttini,Dalbir Nandra,John Etherington,Roger Wolman,David V. Doyle +7 more
TL;DR: Weight-bearing sports activity in women is associated with a 2-3-fold increased risk of radiologic OA (particularly the presence of osteophytes) of the knees and hips, suggesting that duration rather than frequency of training is important.
References
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Journal ArticleDOI
In-Vitro of Measurement of Static Pressure Distribution in Synovial Joints—Part I: Tibial Surface of the Knee
A. M. Ahmed,D. L. Burke +1 more
TL;DR: The results indicate that a significant fraction of the joint compressive load is transmitted through the menisci and that total meniscectomy causes a drastic alteration in the pressure distribution on the tibial surface.
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Experimentally-induced osteoarthritis in the dog.
TL;DR: A large number of investigations were performed at regular intervals before the dogs were killed and a detailed examination was made of all the joint tissues obtained, suggesting that this may be a model which closely simulates clinical osteoarthritis.
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Effects of mechanical loading on the tissues of the rabbit knee.
TL;DR: Changes in subchondral bone and articular cartilage in an animal model of osteoarthrosis preceded changes in content and characterization of cartilage proteoglycans or increased chondrocyte activity as manifested by incorporation of radioactive sulfate.
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Transmission of the Load in the Knee Joint with Special Reference to the Role of the Menisci: Part II: Experimental Results, Discussion and Conclusions
B B Seedhom,D J Hargreaves +1 more
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The Effects of Continuous Compression on Living Articular Cartilage: An Experimental Investigation
Robert B. Salter,Paul Field +1 more
TL;DR: The principle relating to articular cartilage has been formulated and may now be stated: Continuous compression of opposing joint surfaces, whether produced by a mechanical instrument, or by simple immobilization of the joint in a forced position, causes pressure necrosis of articular Cartilage within six days.