Journal ArticleDOI
Mortality among ethylene oxide workers.
TLDR
A mortality study of workers with potential exposure to ethylene oxide at the Texaco Chemical Company Plant in Port Neches, Tex., found no deaths from leukemia, nor were there any statistically significant excesses from any specific causes of death.Abstract:
Because of reports linking an increased risk of leukemia with exposure to ethylene oxide, a mortality study of workers with potential exposure the ethylene oxide at the Texaco Chemical Company Plant in Port Neches, Tex., was undertaken. A total of 767 males with potential exposure to ethylene oxide were identified. Forty-six deaths occurred in this cohort with 80 expected (standardized mortality ration; SMR = 58). No deaths from leukemia were seen, nor were there any statistically significant excesses from any specific causes of death.read more
Citations
More filters
Journal ArticleDOI
Carcinogenic and toxicologic effects of inhaled ethylene oxide and propylene oxide in F344 rats
Dennis W. Lynch,Trent R. Lewis,William J. Moorman,Jeanne R. Burg,David H. Groth,Amir Khan,Larry J. Ackerman,Beverly Y. Cockrell +7 more
TL;DR: PO exposure did not increase the incidence of the three neoplasms associated with EO exposure; however, adrenal pheochromocytomas and proliferative lesions of the nasal cavity were increased in rats exposed to PO.
Journal Article
Molecular dosimetry of ethylene oxide: formation and persistence of 7-(2-hydroxyethyl)guanine in DNA following repeated exposures of rats and mice
TL;DR: Dose-response relationships for 7-HEG were nonlinear in both mice and rats, with the alkylating efficiency of ETO increasing at high exposures.(ABSTRACT TRUNCATED at 400 WORDS)
Journal ArticleDOI
A two-year inhalation study of the carcinogenic potential of ethylene oxide in fischer 344 rats
TL;DR: Fischer 344 rats were exposed to 100, 33, 10, or 0 ppm of ethylene oxide vapor (EtO) by inhalation for 6 hr per day, 5 days per week, for approximately 2 years as mentioned in this paper.
Journal ArticleDOI
Epidemiologic support for ethylene oxide as a cancer-causing agent.
TL;DR: These epidemiologic results provide support for an increased risk of malignancy in individuals with extended and intermittent exposure to low concentrations of ethylene oxide.
References
More filters
Journal ArticleDOI
Analysis of relative survival and proportional mortality
TL;DR: A computer program utilizing cause-age-time-sex-race- race-specific mortality or incidence rates is described, used to determine the expected number of deaths or cases of disease in a cohort.
Journal ArticleDOI
Evaluation of genetic risks of alkylating agents: tissue doses in the mouse from air contaminated with ethylene oxide.
TL;DR: The degree of alkylation of proteins was used to determined tissue doses D t i.e. the concentration of free alkylating agent, integrated over time, in resting male mice exposed for 1–2 h to air containing 1–35 ppm ethylene oxide (EO); the exposure doses were thus 0.03–2% of LD 50.
Journal ArticleDOI
Cancer Mortality Among Chemists
Journal ArticleDOI
Leukemia in workers exposed to ethylene oxide.
TL;DR: Three cases of leukemia that occurred between 1972 and 1977 in a relatively small group of Swedish workers exposed to ethylene oxide are reported.
Journal ArticleDOI
A cohort study of mortality and cancer incidence in ethylene oxide production workers.
TL;DR: The full-time exposed cohort shows a considerable excess mortality deriving mainly from increased mortality from tumours and also from diseases of the circulatory system, but ethylene oxide and ethylene dichloride are the prime suspects.