Journal ArticleDOI
Multiple organ toxicity from addition of erythromycin to long-term lovastatin therapy.
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TLDR
A patient who had taken lovastatin for 7 years received erythromycin before dental procedures and multiple organ toxicity developed, manifested as rhabdomyolysis, acute renal failure, pancreatitis, ileus, livedo reticularis, and elevated aminotransferase values, without liver injury.Abstract:
A patient who had taken lovastatin for 7 years received erythromycin before dental procedures. Multiple organ toxicity developed, manifested as rhabdomyolysis, acute renal failure, pancreatitis, ileus, livedo reticularis, and elevated aminotransferase values, without liver injury. No previouread more
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Statin Adverse Effects: A Review of the Literature and Evidence for a Mitochondrial Mechanism
TL;DR: It is hypothesized, and provided evidence, that the demonstrated mitochondrial mechanisms for muscle AEs have implications to other nonmuscle AEs in patients treated with statins, and both theoretical and empirical considerations suggest that mitochondrial dysfunction may also underlie many nonmuscles statin AEs.
Journal ArticleDOI
Pharmacokinetic interactions between protease inhibitors and statins in HIV seronegative volunteers: ACTG Study A5047.
Carl J. Fichtenbaum,John G. Gerber,Susan L. Rosenkranz,Yoninah Segal,Judith A. Aberg,Terrence F. Blaschke,Beverly Alston,Fang Fang,Bradley W. Kosel,Francesca T. Aweeka +9 more
TL;DR: SimVastatin should be avoided and atorvastatin may be used with caution in persons taking RTV and SQVsgc, and pravastatin does not alter the NFV pharmacokinetics, and thus appears to be safe for concomitant use.
Journal ArticleDOI
Rhabdomyolysis and HMG-CoA Reductase Inhibitors
TL;DR: Rhabdomyolysis is a rare but clinically important adverse event of statin monotherapy or combination therapy and thorough understanding of this condition may help prevent or minimize adverse health outcomes in patients receiving statin therapy.
Journal ArticleDOI
Drug-induced pancreatitis : incidence, management and prevention.
TL;DR: The epidemiology, diagnosis, management and prevention of drug-induced pancreatitis is reviewed and drugs and classes of drugs strongly implicated as causing acute pancreatitis, based on well documented case reports, are discussed in detail.
Journal ArticleDOI
Grapefruit juice increases serum concentrations of atorvastatin and has no effect on pravastatin.
TL;DR: The effect of grapefruit juice on the pharmacokinetics of atorvastatin and pravastatin is studied and it is shown that grapefruit Juice greatly increases the bioavailability of lovastsatin and simvastsatin.