Journal ArticleDOI
Musculoskeletal changes in children prenatally exposed to polychlorinated biphenyls and related compounds (Yu-Cheng children).
TLDR
The shorter height and decreased total lean mass and soft tissue content were only seen in the Yu-Cheng children who were the first born after the ingestion, but not in subsequent children, likely due to decreased body burdens of the PCBs and related contaminants over time in the mothers.Abstract:
Fifty-five Yu-Cheng (oil-disease) children born between 1978 and 1985 to mothers who ate PCB-contaminated rice oil in 1978-1979 were studied and compared to age- and sex-matched control subjects in 1991. The children's growth profiles, bone mineral density and soft tissue composition, joint laxity, and serum parathyroid hormone, vitamin D, calcium, alkaline phosphatase, and phosphate were compared. The Yu-Cheng children were 3.1 cm (p < .05) smaller and had less total lean mass and soft tissue mass as compared to the matched control subjects. All other parameters studied were similar in both groups. The shorter height and decreased total lean mass and soft tissue content were only seen in the Yu-Cheng children who were the first born after the ingestion, but not in subsequent children. This was most likely due to decreased body burdens of the PCBs and related contaminants over time in the mothers.read more
Citations
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Journal ArticleDOI
Effects of PCB exposure on neuropsychological function in children.
TL;DR: It is revealed that the PCB residues in environmental media and human tissues may not closely resemble any of the commercial PCB mixtures, depending on source of exposure, bioaccumulation through the food chain, and weathering of PCBs in the environment.
Journal ArticleDOI
Effects of environmental exposure to polychlorinated biphenyls and dioxins on cognitive abilities in Dutch children at 42 months of age
Svati Patandin,Caren I. Lanting,Paul G.H. Mulder,Eric Boersma,Pieter J. J. Sauer,Nynke Weisglas-Kuperus +5 more
TL;DR: In utero exposure to "background" PCB concentrations is associated with poorer cognitive functioning in preschool children, and children of mothers at the upper end of exposure are especially at risk.
Journal ArticleDOI
Epidemiologic evidence of relationships between reproductive and child health outcomes and environmental chemical contaminants
Donald T. Wigle,Tye E. Arbuckle,Michelle C. Turner,Annie Bérubé,Qiuying Yang,Shiliang Liu,Daniel Krewski +6 more
TL;DR: This review summarizes the level of epidemiologic evidence for relationships between prenatal and/or early life exposure to environmental chemical contaminants and fetal, child, and adult health and points to three main needs.
Book
PCBs: Recent Advances in Environmental Toxicology and Health Effects
TL;DR: A comprehensive and extensive treatment of the very latest findings on all significant subjects relating to PCBs and their health risks is given in this paper, which represents the most up-to-date research by scientists in government, private industry, and academia.
Journal ArticleDOI
Effects of environmental exposure to polychlorinated biphenyls and dioxins on birth size and growth in Dutch children
TL;DR: In utero exposure to environmental levels of PCBs is negatively associated with birth weight and postnatal growth until 3 mo of age, which should be avoided by reducing maternal PCB and dioxin body burden, and consequently fetal exposure to these pollutants.
References
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Congenital poisoning by polychlorinated biphenyls and their contaminants in Taiwan
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TL;DR: The exposed children showed delay of developmental milestones, deficits on formal developmental testing, and abnormalities on behavioral assessment, most consistent with a generalized disorder of ectodermal tissue.
Journal ArticleDOI
The effect of intrauterine PCB exposure on visual recognition memory.
TL;DR: The relation between prenatal exposure and visual recognition was not mediated by the neonatal deficits, suggesting that intrauterine PCB exposure may have a delayed effect on central nervous system (CNS) functioning.
Journal ArticleDOI
Neonatal effects of transplacental exposure to PCBs and DDE.
Walter J. Rogan,Beth C. Gladen,James D. McKinney,Nancy Carreras,Pam Hardy,James Thullen,Jon Tinglestad,Mary Tully +7 more
TL;DR: The results of these tests showed that higher PCB levels were associated with hypotonicity and hyporeflexia and that higher DDE levels wereassociated with hypore flexia.
Journal ArticleDOI
Polychlorinated biphenyls (PCBs) and dichlorodiphenyl dichloroethene (DDE) in human milk: effects of maternal factors and previous lactation.
Walter J. Rogan,Beth C. Gladen,J D McKinney,N Carreras,P Hardy,J Thullen,J Tingelstad,M Tully +7 more
TL;DR: Overall, values for DDE in this study are within the range of those found previously, whereas those for PCBs are somewhat higher, and levels decline both with time spent breast-feeding and with number of children nursed.