Journal ArticleDOI
Myeloperoxidase: Contribution to the Microbicidal Activity of Intact Leukocytes
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TLDR
The azide-insensitive antimicrobial systems are more highly developed in peroxidase-negative leukocyte than in normal leukocytes, thus suggesting an adaptation.Abstract:
Azide and, to a lesser extent, cyanide inhibit the microbicidal activity of myeloperoxidase and of intact normal leukocytes, but they have little or no effect on peroxidase-negative leukocytes. The contribution of the azide-sensitive (peroxidase-dependent?) systems to the total microbicidal activity of normal leukocytes is considerable. The azide-insensitive antimicrobial systems are more highly developed in peroxidase-negative leukocytes than in normal leukocytes, thus suggesting an adaptation.read more
Citations
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The NOX Family of ROS-Generating NADPH Oxidases: Physiology and Pathophysiology
Karen Bedard,Karl-Heinz Krause +1 more
TL;DR: This review summarizes the current state of knowledge of the functions of NOX enzymes in physiology and pathology.
Journal ArticleDOI
Oxygen-dependent microbial killing by phagocytes (second of two parts).
TL;DR: Since Metschnikoff's discovery, hundreds of scientists studying dozens of species have reported thousands of studies on these cells, perhaps the most widely recognized of which are those of the eminent English scientists.
Journal ArticleDOI
Myeloperoxidase: friend and foe
TL;DR: It is concluded that the MPO system plays an important role in the microbicidal activity of phagocytes and the role of theMPO system in tissue injury.
Journal Article
Flow cytometric studies of oxidative product formation by neutrophils: a graded response to membrane stimulation.
David A. Bass,J W Parce,Lawrence R. DeChatelet,Pamela Szejda,Michael C. Seeds,Michael J. Thomas +5 more
TL;DR: The data indicate that the DCFH oxidation assay is quantitatively related to the oxidative metabolic burst of PMNL, and they strongly suggest that the reaction is mediated by H2O2 generated by the PMNL.
Journal ArticleDOI
Inside the neutrophil phagosome: oxidants, myeloperoxidase, and bacterial killing.
TL;DR: Neutrophils are one of the professional phagocytes in humans that ingest bacteria into intracellular spaces and are involved in phagocytosis.
References
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Journal ArticleDOI
In Vitro Bactericidal Capacity of Human Polymorphonuclear Leukocytes: Diminished Activity in Chronic Granulomatous Disease of Childhood
TL;DR: The deficiency of bactericidal capacity and the minimal degranulation after active phagocytosis by the PMN of these children with an inherited syndrome suggest that separate metabolic processes are involved in phagocytetosis and in intracellular digestion.
Journal ArticleDOI
Myeloperoxidase-Halide-Hydrogen Peroxide Antibacterial System
TL;DR: Myeloperoxidase, at high concentrations, exerted an antibacterial effect on L. acidophilus in the absence of added halide, which also was temperature- and catalase-sensitive, and suggests that, under the conditions employed, the antibacterial properties of a weak acid extract of guinea pig leukocytes is due, in part, to its peroxid enzyme content, particularly if a halide is present in the reaction mixture.
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Leukocyte myeloperoxidase deficiency and disseminated candidiasis: the role of myeloperoxidase in resistance to Candida infection
Robert I. Lehrer,Martin J. Cline +1 more
TL;DR: The findings suggest that hereditary MPO deficiency is transmitted as an autosomal recessive characteristic, that the homozygous state conveys enhanced susceptibility to disseminated candidiasis, and that MPO is necessary for candidacidal activity in human neutrophils.
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Biochemical Aspects of Phagocytosis
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Studies of the Metabolic Activity of Leukocytes from Patients with a Genetic Abnormality of Phagocytic Function
TL;DR: It appears that the stimulation of respiration with the formation of hydrogen peroxide and stimulation of the direct oxidative pathway of glucose metabolism are closely linked to degranulation and intracellular killing of bacteria by polymorphonuclear leukocytes.
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