Journal ArticleDOI
N′-(4-Methoxybenzylidene)methoxyformohydrazide
TLDR
There are two molcules in the asymmetric unit of the title compound, C10H12N2O3, with almost identical conformations as mentioned in this paper, and the crystal structure is stabilized by inter-molecular N-H⋯O hydrogen bonds.Abstract:
There are two molecules in the asymmetric unit of the title compound, C10H12N2O3, with almost identical conformations. The crystal structure is stabilized by intermolecular N—H⋯O hydrogen bonds.read more
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(E)-Ethyl N′-[1-(4-methoxyphenyl)ethylidene]hydrazinecarboxylate
TL;DR: The benzene rings of C11H14N2O3 are stacked with their centroids separated by 3.777 (1) A, indicating π−π inter-actions as mentioned in this paper.
Journal ArticleDOI
(E)-Methyl N′-(4-hydroxybenzylidene)hydrazinecarboxylate
TL;DR: In the title compound, C9H10N2O3, the hydroxy group and the C=N—N unit are coplanar with the benzene ring, indicating weak π–π interactions.
Journal ArticleDOI
Ethyl N'-[(E)-4-hydroxy-benzyl-idene]hydrazinecarboxyl-ate at 123 K.
TL;DR: The molecule of the title compound, C10H12N2O3, adopts a trans configuration with respect to the C=N bond, and the dihedral angle between the benzene ring and the hydrazinecarboxylate plane is 14.6 (1)°.
Journal ArticleDOI
(E)-Ethyl N'-(4-bromo-benzyl-idene)hydrazinecarboxyl-ate.
TL;DR: The title compound, C10H11BrN2O2, crystallizes with two independent molecules in the asymmetric unit, in which the dihedral angles between the benzene ring and the hydrazine carboxylic acid mean plane are 3.0 (4) and 45.3‽(3)°.
Journal ArticleDOI
(E)-Methyl N'-(2-hydr-oxy-3-methoxy-benzyl-idene)hydrazinecarboxyl-ate.
TL;DR: In this article, the title compound, C10H12N2O4, adopts a trans configuration with respect to the C=N double bond and the non-H atoms are essentially coplanar, with a maximum deviation of 0.015
References
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Journal ArticleDOI
2-(oxadiazolyl)- and 2-(thiazolyl)imidazo[1,2-a]pyrimidines as agonists and inverse agonists at benzodiazepine receptors.
TL;DR: Replacing the oxadiazole group by thiazole gave compounds such as 23 which binds to the benzodiazepine receptor but exhibits the intrinsic activity of a partial inverse agonist in vivo.
Journal ArticleDOI
Design, synthesis and antiinflammatory activity of some 1,3,4-oxadiazole derivatives.
TL;DR: Some of the newly synthesized derivatives were better analgesics than the reference drug as observed from the percentage writhing inhibition in the p-benzoquinone (PBQ)-induced writhing test in mice.
Journal ArticleDOI
Design, synthesis, and evaluation of Phe-Gly mimetics: heterocyclic building blocks for pseudopeptides.
TL;DR: Enantiopure heterocyclic Boc-protected Phe-Gly dipeptidomimetics containing 1,3, 4-oxadiazole, 1,2,4-ox adenosine ring systems have been synthesized as building blocks in the synthesis of pseudopeptides.
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Hypervalent iodine oxidation of N-acylhydrazones and N- phenylsemicarbazone: An efficient method for the synthesis of derivatives of 1,3,4-oxadiazoles and △^3-1,3,4- oxadiazolines
Ruiyang Yang,Lixin Dai +1 more
TL;DR: In this paper, it was shown that the oxidation of aldehyde N-acylhydrazones by PIDA in methanolic sodium acetate gave 2,5-disubstituted 1,3,4-oxadiazoles in good yields.
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Oxidative Cyclization of Aromatic Aldehyde N‐Acylhydrazones by bis(Trifluoroacetoxy)iodobenzene
TL;DR: In this paper, aromatic aldehyde N−acylhydrazones were oxidized into 2,5disubstituted 1,3,4−oxadiazoles with bis(trifluoroacetoxy)iodobenzene in CHCl3 or DMSO at room temperature in good to excellent yields.