Journal ArticleDOI
N-Bromosuccinimide in Acetonitrile: A Mild and Regiospecific Nuclear Brominating Reagent for Methoxybenzenes and Naphthalenes
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This article is published in Journal of Organic Chemistry.The article was published on 1995-08-01. It has received 167 citations till now. The article focuses on the topics: Reagent & N-Bromosuccinimide.read more
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Use of Bromine and Bromo-Organic Compounds in Organic Synthesis
TL;DR: The use of bromine and different bromo-organic compounds in organic synthesis is outlined and the scope of these reagents for various organic transformations such as bromination, cohalogenation, oxidation, cyclization, ring-opening reactions, substitution, rearrangement, hydrolysis, catalysis, etc is described briefly.
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Novel potent ligands for the central nicotinic acetylcholine receptor: synthesis, receptor binding, and 3D-QSAR analysis.
TL;DR: This work describes the synthesis of six novel series of potent ligands with nanomolar affinity for the alpha4beta2 nAChR subtype using the GRID/GOLPE methodology, and reveals that the steric interactions between the target and the compounds are of major importance for the affinity.
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A Novel Palladium-Mediated Coupling Approach to 2,3-Disubstituted Benzo[ b ]thiophenes and Its Application to the Synthesis of Tubulin Binding Agents
TL;DR: Flexible, convergent access to 2,3-disubstituted benzo[b]thiophenes has been developed and this method has been applied to the synthesis of some novel tubulin binding agents.
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Gold‐Catalyzed Halogenation of Aromatics by N‐Halosuccinimides
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Palladium-Catalyzed Asymmetric Synthesis of Silicon-Stereogenic Dibenzosiloles via Enantioselective C–H Bond Functionalization
TL;DR: A Pd-catalyzed asymmetric synthesis of Si-stereogenic dibenzosiloles is developed through enantioselective C-H bond functionalization of prochiral 2-(arylsilyl)aryl triflates.