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Open AccessJournal ArticleDOI

N,N‐dimethyltryptamine and Amazonian ayahuasca plant medicine

TLDR
Assessment of potential ayahuasca and N,N-dimethyltryptamine (DMT) integration with contemporary healthcare seeks to provide a summary of selected literature regarding the mechanisms of action of DMT andAyahuasca; and assess to what extent the state of research can explain reports of unusual phenomenology.
Abstract
Reports have indicated possible uses of ayahuasca for the treatment of conditions including depression, addictions, post‐traumatic stress disorder, anxiety and specific psychoneuroendocrine immune system pathologies. The article assesses potential ayahuasca and N,N‐dimethyltryptamine (DMT) integration with contemporary healthcare. The review also seeks to provide a summary of selected literature regarding the mechanisms of action of DMT and ayahuasca; and assess to what extent the state of research can explain reports of unusual phenomenology.

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Journal ArticleDOI

Arketamine, a new rapid-acting antidepressant: A historical review and future directions

TL;DR: A phase 2 clinical trial of arketamine in treatment-resistant patients with major depressive disorder (MDD) and other psychiatric disorders, such as bipolar disorder and post-traumatic stress disorder, is underway as mentioned in this paper .
Journal ArticleDOI

N,N‐dimethyltryptamine and Amazonian ayahuasca plant medicine

TL;DR: Assessment of potential ayahuasca and N,N-dimethyltryptamine (DMT) integration with contemporary healthcare seeks to provide a summary of selected literature regarding the mechanisms of action of DMT andAyahuasca; and assess to what extent the state of research can explain reports of unusual phenomenology.
Journal ArticleDOI

Changes in mental health, wellbeing and personality following ayahuasca consumption: Results of a naturalistic longitudinal study

TL;DR: In this article , the effects of facilitated ayahuasca consumption in naive participants on mental health, alcohol and substance use/abuse, personality traits, relationships, and connection to self and spirituality were investigated.
Journal ArticleDOI

Application of Deuterated N,N-Dimethyltryptamine in the Potential Treatment of Psychiatric and Neurological Disorders.

TL;DR: The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online as mentioned in this paper , which is calculated using a weighted average of the number of clicks on a page at altmetric.com with additional details about the score.
Journal ArticleDOI

Liquid chromatography-tandem mass spectrometry method for the bioanalysis of N,N-dimethyltryptamine (DMT) and its metabolites DMT-N-oxide and indole-3-acetic acid in human plasma.

TL;DR: In this paper , a high performance liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for quantification of DMT and its major metabolites indole-3-acetic acid (IAA) and DMT-Noxide (DMT-NO) was developed and validated.
References
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TL;DR: Gardner's theory of multiple intelligences as discussed by the authors has become widely accepted as one of the seminal ideas of the twentieth century and continues to attract attention all over the world and has been extensively studied.
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Perceptions of epigenetics

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Facing Up to the Problem of Consciousness

TL;DR: In this article, a non-reductive theory based on principles of structural coherence and organizational invariance and a double-aspect theory of information is proposed to explain the complexity of the problem of consciousness.
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Perception's shadow: long-distance synchronization of human brain activity.

TL;DR: In this article, the authors show that only face perception induces a long-distance pattern of synchronization, corresponding to the moment of perception itself and to the ensuing motor response, and suggest that this desynchronization reflects a process of active uncoupling of the underlying neural ensembles that is necessary to proceed from one cognitive state to another.
Journal Article

Towards a neurobiological theory of consciousness

TL;DR: The neural basis of very short-term memory especia needs more study, and several lines of work are outfits that might advance the understanding of the neural mechanisms involved.
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