Journal ArticleDOI
Naloxone-reversible peripheral electroanalgesia in intact and spinal rats.
TLDR
Peripheral electrical stimulation of the rat produced a "dose-dependent" analgesia both in intact and in spinal animals, and Naloxone, a narcotic antagonist, almost completely reversed this analgesia.About:
This article is published in European Journal of Pharmacology.The article was published on 1977-10-01. It has received 96 citations till now. The article focuses on the topics: Narcotic antagonist & (+)-Naloxone.read more
Citations
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Journal ArticleDOI
A perceptual-defensive-recuperative model of fear and pain
TL;DR: A model of fear and pain is presented in which the two are assumed to activate totally different classes of behavior, and it is assumed that fear triggers the endorphin mechanism, thereby inhibiting pain motivation and recuperative behaviors that might compete with effective defensive behavior.
Journal ArticleDOI
Transcutaneous electrical nerve stimulation: Basic science mechanisms and clinical effectiveness
TL;DR: TENS is a noninvasive modality that is easy to apply with relatively few contraindications, however, the clinical efficacy of TENS will remain equivocal until the publication of sufficient numbers of high quality, randomized, controlled clinical trials.
Journal ArticleDOI
The influence of naloxone on analgesia produced by peripheral conditioning stimulation.
Bengt Sjölund,Margareta Eriksson +1 more
TL;DR: To see whether the analgesia experienced by the chronic pain patients is mediated via links utilizing endorphins, the opiate antagonist naloxone was administered to these patients under double-blind conditions, saline being used as a placebo, and it was found that 6 out of 10 patients receiving acupuncture-like stimulation but none out of10 patients receiving high frequency stimulation of skin nerves, reported an inhibition of the stimulation-produced analgesia by nAloxone.
Journal Article
Spinal Blockade of Opioid Receptors Prevents the Analgesia Produced by TENS in Arthritic Rats
TL;DR: This study investigated the role of mu, delta, and kappa opioid receptors in antihyperalgesia produced by low- and high-frequency TENS by using an animal model of inflammation to address the neurophysiological basis for the actions of TENS.
Book
Control of Nociceptive Transmission in the Spinal Cord
TL;DR: Soldering method comprises placing a cadmium-zinc-lead solder on a copper base and exposing the solder joint to about 200 DEG C. for at least one hour to produce a copper-cadmium -zinc ternary interface barrier layer which inhibits migration.
References
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Journal ArticleDOI
Analgesia mediated by a direct spinal action of narcotics.
Tony L. Yaksh,T. A. Rudy +1 more
TL;DR: Narcotic analgetics administered directly into the spinal subarachnoid space of the rat via a chronically inserted catheter produce a potent analgesia that can be antagonized by naloxone.
Journal ArticleDOI
Immunohistochemical studies using antibodies to leucine-enkephalin: Initial observations on the nervous system of the rat
TL;DR: Findings provide morphological support for the hypothesis that enkephalins are contained in nerve terminals close to opiate receptors as revealed by biochemical techniques.
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Central nervous system mechanisms of analgesia.
David J. Mayer,Donald D. Price +1 more
TL;DR: The intent of this review is to examine and synthesize the extensive progress that has been made in the last few years describing the anatomical, physiological and neurohumoral substrates of neural systems which modulate pain perception.
Journal ArticleDOI
Antagonism of stimulation-produced analgesia by naloxone, a narcotic antagonist
TL;DR: Analgesia produced by focal electrical stimulation of the brain is partially reversed by the narcotic antagonist naloxone and it is suggested that stimulation-produced analgesia may result, at least in part, from release of an endogenous, narcotic-like substance.