Journal ArticleDOI
Naturally occurring quinones as potential bioreductive alkylating agents
Harold W. Moore,Richard Czerniak +1 more
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This article is published in Medicinal Research Reviews.The article was published on 1981-09-01. It has received 202 citations till now.read more
Citations
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Dietary carcinogens and anticarcinogens Oxygen radicals and degenerative diseases
TL;DR: Dietary intake of natural antioxidants could be an important aspect of the body's defense mechanism against these agents of cancer and other age-related diseases.
Journal ArticleDOI
Free radical formation by antitumor quinones
TL;DR: The evidence for a relationship between radical formation and the biological activity of the antitumor quinones is evaluated and it is suggested that cardiotoxicity and skin toxicity may also be related to oxygen radical formation.
Journal ArticleDOI
Redox and addition chemistry of quinoid compounds and its biological implications
Anders Brunmark,Enrique Cadenas +1 more
TL;DR: The detailed chemical mechanisms by which quinoid compounds exert cytotoxic, mutagenic and carcinogenic effects are considered individually in relation to redox cycling, alterations of thiol balance and Ca++ homeostasis, and covalent binding.
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Antimutagens and anticarcinogens: a survey of putative interceptor molecules.
TL;DR: Although they serve as a first line of defense against mutagens and carcinogens, many interceptor molecules are under‐investigated with regard to their spectra of activity and their possible relevance to prophylaxis or treatment of human disease states.
References
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Journal ArticleDOI
Mitomycins and porfiromycin: chemical mechanism of activation and cross-linking of dna.
V. N. Iyer,Waclaw Szybalski +1 more
TL;DR: In this article, the activation and cross-linking reactions of mitomycins and porfiromycin are discussed in terms of reactive sites on the mitomycin and DNA molecules.
Journal ArticleDOI
Identifying Environmental Chemicals Causing Mutations and Cancer
TL;DR: Newly developed short-term tests, most of them assaying for mutagenicity, are discussed as key tools in identifying environmental mutagens and carcinogens.
Journal ArticleDOI
NADPH cytochrome P-450 reductase activation of quinone anticancer agents to free radicals
TL;DR: It is postulate that the formation of the "site-specific free radical/ intermediate is central to the cytotoxic action of these antibiotics.
Journal ArticleDOI
Stereochemistry of intercalation: interaction of daunomycin with DNA.
TL;DR: Daunomycin, a glycosidic anthracycline antibiotic from Streptomyces peucetius, is being used in the treatment of acute leukaemia and solid tumours in man due to complex formation with the DNA of deoxyribonucleoprotein4.
Related Papers (5)
Mitomycins and porfiromycin: chemical mechanism of activation and cross-linking of dna.
V. N. Iyer,Waclaw Szybalski +1 more