Journal ArticleDOI
Neurotransmitters extraction by local intracerebral dialysis in anesthetized rats.
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TLDR
A new technique for in vivo neurotransmitter extraction was developed by chronically implanted in the caudate or the thalamus of rats and measurable amounts of dopamine and norepinephrine were recovered from the perfusion fluid.Abstract:
A new technique for in vivo neurotransmitter extraction was developed. Perfusion U shaped cannulae were chronically implanted in the caudate or the thalamus of rats. A segment of the cannula was a piece of dialysis tube of molecular weight cut off 1000. Measurable amounts of dopamine and norepinephrine were recovered from the perfusion fluid. Intraperitoneal amphetamine 10 mg/kg increased dopamine output from the caudate but not from the thalamus. The potential applications of this technique are discussed.read more
Citations
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Journal ArticleDOI
Microdialysis—Theory and application
TL;DR: Article de synthese sur la technique de microdialyse permettant de determiner en continu et in vivo les concentrations des substances interstitielles dans l'encephale.
Journal ArticleDOI
Food reward and cocaine increase extracellular dopamine in the nucleus accumbens as measured by microdialysis.
Luis Hernandez,Bartley G. Hoebel +1 more
TL;DR: At the site in the nucleus accumbens where rats will administer amphetamine to themselves, injections of amphetamine or cocaine increased extracellular dopamine five-fold, thus amphetamine and cocaine increase dopamine in a behavior reinforcement system which is normally activated by eating.
Journal ArticleDOI
Microdialysis studies of brain norepinephrine, serotonin, and dopamine release during ingestive behavior. Theoretical and clinical implications.
TL;DR: The data support the hypothesis that dopamine systems projecting to the nucleus accumbens and other forebrain areas from the mid-brain ventral tegmental area (VTA) are important for approach and positive reinforcement in ingestive behavior and self-stimulation and propose as a working hypothesis that several varieties of hyperphagia leading to obesity have a common element.
Journal ArticleDOI
A small, removable microdialysis probe.
TL;DR: Tests in awake rats with probes in the nucleus accumbens showed stable amounts of catecholamines and metabolites collected during repeated 20 min samples, and absolute recovery measured in picograms was independent of the perfusate flow rate inside the probe.
Journal ArticleDOI
Effects of nicotine and mecamylamine-induced withdrawal on extracellular dopamine and acetylcholine in the rat nucleus accumbens.
TL;DR: ACh release during withdrawal, coupled with the decrease in extracellular DA may play a role in the aversive aspects of nicotine withdrawal that contribute to dependency.
References
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Journal ArticleDOI
The Biochemical Basis of Neuropharmacology
TL;DR: The fifth edition of this volume features two new chapters on topics of current interest: molecular neurobiology and neuromodulation, and all other chapters have been updated.
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Central Catecholamine Neuron Systems: Anatomy and Physiology of the Dopamine Systems
R Y Moore,Floyd E. Bloom +1 more
TL;DR: This chapter seeks to review the present status of the central dopamine neuron systems with particular reference to their structure and function, and puts in perspective those structural and functional properties of these neuron systems that set them at variance with certain other well-defined neuronal circuits.
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In vivo electrochemical detection of catechols in the neostriatum of anaesthetized rats: dopamine or DOPAC?
TL;DR: The DPV method used in conjunction with an electrochemical treatment of this electrode yields stable and reproducible peaks in which catecholamines and AA are resolved from each other, suggesting that the technique may be a useful means of following dopaminergic activity in vivo.
Journal ArticleDOI
A Simple Microelectrode for recording from the Central Nervous System
TL;DR: Steel electrodes, which have the advantages of low noise, low electrode potential, ease of straightening and, in particular, offer the possibility of accurate localization of the recording site, may be made.