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Assunta Imperato
Researcher at Rhône-Poulenc
Publications - 121
Citations - 16065
Assunta Imperato is an academic researcher from Rhône-Poulenc. The author has contributed to research in topics: Dopamine & Acetylcholine. The author has an hindex of 44, co-authored 121 publications receiving 15612 citations. Previous affiliations of Assunta Imperato include University of Cagliari & Aventis Pharma.
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Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats.
G. Di Chiara,Assunta Imperato +1 more
TL;DR: The effect of various drugs on the extracellular concentration of dopamine in two terminal dopaminergic areas, the nucleus accumbens septi (a limbic area) and the dorsal caudate nucleus (a subcortical motor area), was studied in freely moving rats by using brain dialysis as mentioned in this paper.
Journal ArticleDOI
Unresponsiveness to Cannabinoids and Reduced Addictive Effects of Opiates in CB1 Receptor Knockout Mice
Catherine Ledent,Olga Valverde,G Cossu,François Petitet,Jean-François Aubert,Françoise Beslot,Georg Andrees Bohme,Assunta Imperato,Thierry Pedrazzini,Bernard P. Roques,Gilbert Vassart,Walter Fratta,Marc Parmentier +12 more
TL;DR: Observations suggest that the CB1 receptor is involved in the motivational properties of opiates and in the development of physical dependence and extend the concept of an interconnected role of CB1 and opiate receptors in the brain areas mediating addictive behavior.
Journal Article
Opposite effects of mu and kappa opiate agonists on dopamine release in the nucleus accumbens and in the dorsal caudate of freely moving rats.
G. Di Chiara,Assunta Imperato +1 more
TL;DR: Mu agonists, agonists of kappa receptors like U50,488, bremazocine and tifluadom decreased DA release in the accumbens and in the caudate and reduced motor activity.
Journal Article
Preferential stimulation of dopamine release in the nucleus accumbens of freely moving rats by ethanol.
Assunta Imperato,G. Di Chiara +1 more
TL;DR: The results indicate that ethanol preferentially stimulates DA transmission in the mesolimbic system probably by activating the firing activity of meslimbic DA neurons and provide direct evidence that these changes are involved in the motor stimulant effects of ethanol.