Journal ArticleDOI
Neutrophil-to-Lymphocyte Ratio in Acute Cerebral Hemorrhage: a System Review.
Simona Lattanzi,Francesco Brigo,Eugen Trinka,Claudia Cagnetti,Mario Di Napoli,Mauro Silvestrini +5 more
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TLDR
The available evidence about the relationships between the NLR and clinical outcome in patients with acute ICH is highlighted to provide critical insights into the underlying pathophysiology and to identify new potential targets for neuroprotection and develop novel therapeutic strategies.Abstract:
Spontaneous intracerebral hemorrhage (ICH) accounts for approximately 10 to 30% of all acute cerebrovascular events, and it is the type of stroke associated with the highest rates of mortality and residual disability. The inflammatory response is early triggered by hematoma components and can enhance the damage within the hemorrhagic brain. Assessment of peripheral biomarkers of inflammation could contribute to increase knowledge about some of the mechanisms involved in the ICH-induced injury and yield information on the disease course. The neutrophil-to-lymphocyte ratio (NLR) integrates information on both the innate and adaptive compartments of the immunity and represents a reliable measure of the inflammatory burden. The aim of the current review is to highlight the available evidence about the relationships between the NLR and clinical outcome in patients with acute ICH and provide critical insights into the underlying pathophysiology. Since no therapy targeting ICH-induced primary injury has yielded conclusive benefits and ICH treatment remains mainly supportive within a framework of general critical care management, these findings could also contribute to identify new potential targets for neuroprotection and develop novel therapeutic strategies.read more
Citations
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Journal ArticleDOI
Neutrophil-to-lymphocyte ratio and mortality in the United States general population.
TL;DR: In this article, the authors investigated the role of neutrophil-to-lymphocyte ratio (NLR) in predicting mortality in the general population and found that increased NLR was associated with overall mortality.
Journal ArticleDOI
Clinical Significance of Baseline Neutrophil-to-Lymphocyte Ratio in Patients With Ischemic Stroke or Hemorrhagic Stroke: An Updated Meta-Analysis.
Si-ying Song,Xiao-Xi Zhao,Gary Rajah,Chang Hua,Rui-jun Kang,Yi-peng Han,Yuchuan Ding,Ran Meng +7 more
TL;DR: Baseline NLR level is a promising predictor of the clinical outcomes in both ischemic and hemorrhagic stroke, however, future studies are needed to demonstrate the underlying mechanisms and further explain this association.
Journal ArticleDOI
Matrix Metalloproteinases in Acute Intracerebral Hemorrhage
TL;DR: The aim of this review is to summarize the available experimental and clinical evidence about the role of MMPs in brain injury following spontaneous ICH and provide critical insights into the underlying mechanisms.
Journal ArticleDOI
Leukocytes, Collateral Circulation, and Reperfusion in Ischemic Stroke Patients Treated With Mechanical Thrombectomy.
Aurora Semerano,Carlos Laredo,Yashu Zhao,Salvatore Rudilosso,Arturo Renú,Laura Llull,Sergio Amaro,Victor Obach,Anna M. Planas,Xabier Urra,Ángel Chamorro +10 more
TL;DR: In patients treated with mechanical thrombectomy, neutrophil and lymphocyte counts are dynamic parameters associated with hemorrhagic complications and long-term outcome and highlight the dual role of leukocytes in acute stroke.
Journal ArticleDOI
Neutrophil‐to‐lymphocyte ratio predicts hemorrhagic transformation in ischemic stroke: A meta‐analysis
TL;DR: This research explored the predictive effect of NLR for HT in patients with AIS and to determine the best predictive value.
References
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Journal ArticleDOI
Prognostic Role of Neutrophil-to-Lymphocyte Ratio in Solid Tumors: A Systematic Review and Meta-Analysis
Arnoud J. Templeton,Mairéad G McNamara,Bostjan Seruga,Francisco E. Vera-Badillo,Priya Aneja,Alberto Ocaña,Raya Leibowitz-Amit,Guru Sonpavde,Jennifer J. Knox,Ben Tran,Ian F. Tannock,Eitan Amir +11 more
TL;DR: A high NLR is associated with an adverse OS in many solid tumors, and its addition to established prognostic scores for clinical decision making warrants further investigation.
Journal ArticleDOI
Stroke epidemiology: a review of population-based studies of incidence, prevalence, and case-fatality in the late 20th century.
TL;DR: The review shows that the burden of stroke is high and is likely to increase in future decades as a result of demographic and epidemiological transitions in populations and further research that uses the best possible methods are urgently needed in other populations of the world.
Journal Article
Ratio of neutrophil to lymphocyte counts--rapid and simple parameter of systemic inflammation and stress in critically ill.
TL;DR: In the population of 90 ICU oncological patients, rapid serial changes in white blood cell populations are observed, as a response of the immune system to surgical stress, systemic inflammation or sepsis.
Journal ArticleDOI
Central nervous system injury-induced immune deficiency syndrome
Christian Meisel,Jan M. Schwab,Jan M. Schwab,Jan M. Schwab,Konstantin Prass,Andreas Meisel,Ulrich Dirnagl +6 more
TL;DR: Understanding CIDS will allow us to work on developing effective therapeutic strategies, with which the outcome after CNS damage by a host of diseases could be improved by eliminating a major determinant of poor recovery.
Journal ArticleDOI
Association between admission neutrophil to lymphocyte ratio and outcomes in patients with acute coronary syndrome.
Umesh U. Tamhane,Sanjay Aneja,Daniel G. Montgomery,Eva-Kline Rogers,Kim A. Eagle,Hitinder S. Gurm +5 more
TL;DR: Admission NLR is an independent predictor of in-hospital and 6-month mortality in patients with ACS and this relatively inexpensive marker of inflammation can aid in the risk stratification and prognosis of patients diagnosed with ACS.