New clonal strain of Candida auris, Delhi, India
Anuradha Chowdhary,Cheshta Sharma,Shalini Duggal,Kshitij Agarwal,Anupam Prakash,Pradeep K. Singh,Sarika Jain,Shallu Kathuria,Harbans S. Randhawa,Ferry Hagen,Jacques F. Meis +10 more
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A new clonal strain of Candida auris is an emerging etiologic agent of fungemia in Delhi, India In 12 patients in 2 hospitals, it was resistant to fluconazole and genotypically distinct from isolates from South Korea and Japan, as revealed by M13 and amplified fragment length polymorphism typing as mentioned in this paper.Abstract:
A new clonal strain of Candida auris is an emerging etiologic agent of fungemia in Delhi, India In 12 patients in 2 hospitals, it was resistant to fluconazole and genotypically distinct from isolates from South Korea and Japan, as revealed by M13 and amplified fragment length polymorphism typingread more
Citations
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Journal ArticleDOI
Simultaneous Emergence of Multidrug-Resistant Candida auris on 3 Continents Confirmed by Whole-Genome Sequencing and Epidemiological Analyses
Shawn R. Lockhart,Kizee A. Etienne,Snigdha Vallabhaneni,Joveria Farooqi,Anuradha Chowdhary,Nelesh P. Govender,Arnaldo Lopes Colombo,Belinda Calvo,Christina A. Cuomo,Christopher A. Desjardins,Elizabeth L. Berkow,Mariana Castanheira,Rindidzani E. Magobo,Kauser Jabeen,Rana Jawad Asghar,Jacques F. Meis,Brendan R Jackson,Tom Chiller,Anastasia P. Litvintseva +18 more
TL;DR: Candida auris is an emerging healthcare-associated pathogen associated with high mortality, and WGS analysis suggests nearly simultaneous, and recent, independent emergence of different clonal populations on 3 continents.
Journal ArticleDOI
First hospital outbreak of the globally emerging Candida auris in a European hospital
Silke Schelenz,Ferry Hagen,Johanna Rhodes,Alireza Abdolrasouli,Anuradha Chowdhary,Anne Hall,Lisa Ryan,Joanne Shackleton,Richard Trimlett,Jacques F. Meis,Darius Armstrong-James,Matthew C. Fisher +11 more
TL;DR: This ongoing outbreak with genotypically closely related C. auris highlights the importance of appropriate species identification and rapid detection of cases in order to contain hospital acquired transmission.
Journal ArticleDOI
Candida auris: A rapidly emerging cause of hospital-acquired multidrug-resistant fungal infections globally.
TL;DR: Alarmingly, in a span of only 7 years, this yeast, which is difficult to treat and displays clonal interand intra-hospital transmission, has become widespread across several countries, causing a broad range of healthcare-associated invasive infections.
Journal ArticleDOI
Multidrug-Resistant Candida auris Misidentified as Candida haemulonii: Characterization by Matrix-Assisted Laser Desorption Ionization–Time of Flight Mass Spectrometry and DNA Sequencing and Its Antifungal Susceptibility Profile Variability by Vitek 2, CLSI Broth Microdilution, and Etest Method
Shallu Kathuria,Pradeep Kumar Singh,Cheshta Sharma,Anupam Prakash,Aradhana Masih,Anil Kumar,Jacques F. Meis,Anuradha Chowdhary +7 more
TL;DR: A cautionary approach is recommended for laboratories relying on commercial systems for identification and antifungal susceptibility testing of rare yeasts, as 90% of the isolates characterized by commercial identification systems are misidentified as C. auris.
Book ChapterDOI
Candida, Cryptococcus, and other yeasts of medical importance.
TL;DR: The chapter on Candida, Cryptococcus, and other yeasts of medical importance outlines the taxonomy, epidemiology, and clinical significance of species from as many as 12 yeast genera and contains five tables containing key identification characteristics of yeasts.
References
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Book
PCR protocols : A guide to methods and applications
TL;DR: Basic Methodology: M.A. Innis and D.F. Frohman, RACE: Rapid Amplification of cDNA Ends, and RNA Processing: Apo-B.R. Kwok, Procedure to Minimuze PCR-Product Carry-Over.
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Reference method for broth dilution antifungal susceptibility testing of yeasts : Approved standard
John H. Rex,Clinical +1 more
TL;DR: A method for testing the susceptibility of antifungal agents to yeast that cause invasive fungal infections, including Candida spp.
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Identification of clinically important ascomycetous yeasts based on nucleotide divergence in the 5' end of the large-subunit (26S) ribosomal DNA gene.
TL;DR: Of the 204 described species examined, 21 appeared to be synonyms of previously described organisms, and the relationships among the species are presented.
Related Papers (5)
Simultaneous Emergence of Multidrug-Resistant Candida auris on 3 Continents Confirmed by Whole-Genome Sequencing and Epidemiological Analyses
Shawn R. Lockhart,Kizee A. Etienne,Snigdha Vallabhaneni,Joveria Farooqi,Anuradha Chowdhary,Nelesh P. Govender,Arnaldo Lopes Colombo,Belinda Calvo,Christina A. Cuomo,Christopher A. Desjardins,Elizabeth L. Berkow,Mariana Castanheira,Rindidzani E. Magobo,Kauser Jabeen,Rana Jawad Asghar,Jacques F. Meis,Brendan R Jackson,Tom Chiller,Anastasia P. Litvintseva +18 more