Journal ArticleDOI
New positive inotropic agents in the treatment of congestive heart failure. Mechanisms of action and recent clinical developments. 1.
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Newer Phosphodiesterase Inhibitors Among the most promising recent developments in positive inotropic agents has been the description of a class of drugs that have both potent positive and negative inotropic properties.Abstract:
Newer Phosphodiesterase Inhibitors Among the most promising recent developments in positive inotropic agents has been the description of a class of drugs that have both potent positive inotropic an...read more
Citations
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Journal ArticleDOI
Executive summary of the guidelines on the diagnosis and treatment of acute heart failure: the Task Force on Acute Heart Failure of the European Society of Cardiology.
Markku S. Nieminen,Silvia G. Priori,Maria Angeles Alonso Garcia,Andrzej Budaj,Enrique Fernandez Burgos,John Lekakis,Gianfranco Mazzotta,Otto A. Smiseth,Kenneth Dickstein,María G. Crespo-Leiro,Roberto Ferrari +10 more
TL;DR: It is of great importance that guidelines and recommendations are presented in formats that are easily interpreted and their implementation programmes must also be well conducted.
Journal ArticleDOI
The Medical Review Article: State of the Science
TL;DR: It is indicated that current medical reviews do not routinely use scientific methods to identify, assess, and synthesize information.
Journal ArticleDOI
Low vitamin D status: a contributing factor in the pathogenesis of congestive heart failure?
Armin Zittermann,Stefanie S. Schleithoff,Gero Tenderich,Heiner K. Berthold,Reiner Körfer,Peter Stehle +5 more
TL;DR: The low vitamin D status can explain alterations in mineral metabolism as well as myocardial dysfunction in the CHF patients, and it may therefore be a contributing factor in the pathogenesis of CHF.
Journal ArticleDOI
Adrenergic nervous system in heart failure: pathophysiology and therapy.
TL;DR: The present review discusses the role of the ANS in cardiac physiology and in HF pathophysiology, the mechanisms of regulation of ANS activity and how they go awry in chronic HF, methods of measuring AnS activity in HF, the molecular alterations in heart physiology that occur inHF, along with their pharmacological and therapeutic implications, and, finally, drugs and other therapeutic modalities used in HF treatment that target or affect the ANs and its effects on the failing heart.
References
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Journal ArticleDOI
Decreased catecholamine sensitivity and beta-adrenergic-receptor density in failing human hearts.
Michael R. Bristow,Ginsburg R,Minobe W,Cubicciotti Rs,Sageman Ws,Keith G. Lurie,Billingham Me,Harrison Dc,Stinson Eb +8 more
TL;DR: It is concluded that in failing human hearts a decrease in beta-receptor density leads to subsensitivity of the beta-adrenergic pathway and decreased beta-agonist-stimulated muscle contraction.
Journal ArticleDOI
Biochemical properties of hormone-sensitive adenylate cyclase.
Elliott M. Ross,A. G. Gilman +1 more
Journal ArticleDOI
Plasma norepinephrine in congestive heart failure
James Thomas,Bernard H. Marks +1 more
TL;DR: It is demonstrated that the plasma norepinephrine concentration is directly related to the degree of left ventricular dysfunction in patients with congestive heart failure and suggested that beta adrenergic receptors are desensitized in these patients and that this desensitization contributes to the observed alterations in myocardial contractility.
Journal ArticleDOI
Survival in men with severe chronic left ventricular failure due to either coronary heart disease or idiopathic dilated cardiomyopathy
Joseph A. Franciosa,Joseph A. Franciosa,Mary M. Wilen,Mary M. Wilen,Susan Ziesche,Susan Ziesche,Jay N. Cohn,Jay N. Cohn +7 more
TL;DR: This study followed up 182 patients with chronic left ventricular failure who were symptomatic despite therapy and found that the incidence of sudden death was similar in patients with coronary artery disease and idiopathic dilated cardiomyopathy.
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