Journal ArticleDOI
Nigella sativa seed extract and its bioactive compound thymoquinone: the new melanogens causing hyperpigmentation in the wall lizard melanophores
Sharique A. Ali,Keisham V Meitei +1 more
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TLDR
The effects of the lyophilized seed extract of Nigella sativa and its active ingredient, thymoquinone, were studied on the isolated melanophores of the wall lizard to find the mechanism of skin darkening at the cellular level.Abstract:
Objective The effects of the lyophilized seed extract of Nigella sativa and its active ingredient, thymoquinone, were studied on the isolated melanophores of the wall lizard to find the mechanism of skin darkening at the cellular level.
Methods The integumental melanophores of the wall lizard, Hemidactylus flaviviridis, were assayed using the mean melanophore size index and their responses were recorded in the presence of various concentrations of the plant extract, thymoquinone, specific antagonists and potentiator.
Key findings Significant skin darkening activity of the extract of N. sativa and thymoquinone was observed on the isolated melanophores of the wall lizard. The pigment cells responded by distinct dispersion leading to skin darkening. The effect was physiologically significant as re-immersion in physiological saline made the melanophores return to their normal intermediate state. These melanin dispersal effects were antagonized by atropine as well as hyoscine and were also found to be highly potentiated by neostigmine, an anticholinesterase agent.
Conclusions These findings suggest that the extract of N. sativa, as well as its active principle, mimic the action of acetylcholine in melanin dispersion leading to skin darkening via stimulation of cholinergic receptors of muscarinic nature within the melanophores of wall lizard. This study opens new vistas for the use of N. sativa active ingredient, thymoquinone, as a novel melanogen for its clinical application in skin disorders such as hypopigmentation or vitiligo.read more
Citations
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Journal ArticleDOI
Dermatological effects of Nigella sativa
TL;DR: In this article, the literature pertaining to dermatological effects of N. sativa is reviewed, the first review in this subject, and it is expected that this review stimulates further studies on the dermatology effects and application of the plant.
Journal ArticleDOI
Optimization of ethosomes for topical thymoquinone delivery for the treatment of skin acne
Hina Kausar,Mohd Mujeeb,Abdul Ahad,Thasleem Moolakkadath,Mohd. Aqil,Adil Ahmad,Habban Akhter,Habban Akhter +7 more
TL;DR: The developed thymoquinone loaded ethosomes formulation can be used as an effective treatment option for acne vulgaris and various skin disorders and was concluded that the developed formulation was safe, less irritant and well tolerable formulation for topical delivery.
Journal ArticleDOI
Comparing Nigella sativa Oil and Fish Oil in Treatment of Vitiligo
TL;DR: Nigella sativa oil and fish oil were effective in reduction the size of patient’s lesions; however, Nigella sativas was more effective in comparison to the fish oil.
Journal ArticleDOI
A Review on the Cosmeceutical and External Applications of Nigella sativa.
TL;DR: The aim of this article is to provide a detailed survey of the literature of cosmeceutical and external applications of N. sativa which is expected to stimulate further studies on this subject.
Journal Article
Links between the Prophet Muhammad (PBUH) recommended foods and disease management: A review in the light of modern superfoods.
TL;DR: A brief survey of the literature on scientifically based significance of these superfoods carried out by various researchers and exploration of a wide spectrum of their pharmacological actions which include antidiabetic, anticancer, immune modulator, analgesic, anti-inflammatory, and hepatoprotective properties are provided.
References
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Journal ArticleDOI
Fixed oil of Nigella sativa and derived thymoquinone inhibit eicosanoid generation in leukocytes and membrane lipid peroxidation.
TL;DR: The pharmacological properties of the oil support the traditional use of N. sativa and its derived products as a treatment for rheumatism and related inflammatory diseases and is greater than is expected from its content of thymoquinone.
Journal ArticleDOI
The Pigmentary Effector System. VI. The Dual Character of Endocrine Co-Ordination in Amphibian Colour Change
Lancelot Hogben,David Slome +1 more
TL;DR: It is now clearly established that the pituitary gland is an essential agency in determining Amphibian colour change, and it is still possible to entertain the hypothesis that the gland is merely a condition of the response of the melanophores to nervous impulse in efferent fibres supplying the skin.
Journal Article
The in vitro anti-tumor activity of some crude and purified components of blackseed, Nigella sativa L.
TL;DR: TQ and DIM, which are cytotoxic for several types of human tumor cells, may be MDR substrates, and that radical generation may not be critical to their cytotoxicity activity.
Journal ArticleDOI
Cytotoxic and immunopotentiating effects of ethanolic extract of Nigella sativa L. seeds
S.M.K Swamy,Benny K. H. Tan +1 more
TL;DR: Data indicate that CC-5 possesses a potent cytotoxic effect as well as a potentiating effect on the cellular immune response, and the mechanism whereby it produces this needs to be resolved.
Journal ArticleDOI
Adrenergic and Cholinergic Control in the Biology of Epidermis: Physiological and Clinical Significance
TL;DR: The presence of an autocrine adrenergic and cholinergic intra/intercellular signal transduction network in the human epidermis contributes significantly to homeostatic and compensatory responses regulating vital functions in keratinocytes and melanocytes.
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