Journal ArticleDOI
Nitrate, nitrite and N-nitroso compounds.
S.D. Gangolli,P.A. van den Brandt,V.J. Feron,C. Janzowsky,Jan H. Koeman,Gerrit J.A. Speijers,B. Spiegelhalder,Ronald Walker,J.S. Wishnok +8 more
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TLDR
There is no firm scientific evidence at present to recommend drastic reductions beyond the average levels of nitrate encountered in vegetables grown in keeping with good agricultural practice, and recommendations are made for further animal and human studies to elucidate the potential risks to man from ingested nitrate.About:
This article is published in European Journal of Pharmacology.The article was published on 1994-11-01. It has received 342 citations till now. The article focuses on the topics: Nitrate & Nitrite.read more
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Functional properties of anthocyanins and betalains in plants, food, and in human nutrition
TL;DR: Anthocyanins and betalains both in fresh and also processed fruit and vegetables serve two functions: They improve the overall appearance, but also contribute to consumers' health and well-being.
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Nitrate in vegetables: toxicity, content, intake and EC regulation
TL;DR: This review reports on nitrate content of vegetables in Italy and other European countries, which is of interest to governments and regulators owing to the possible implications for health and to check that controls on the content are effective.
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Food sources of nitrates and nitrites: the physiologic context for potential health benefits
TL;DR: Data call into question the rationale for recommendations to limit nitrate and nitrite consumption from plant foods; a comprehensive reevaluation of the health effects of food sources of nitrates and nitrites is appropriate.
Journal ArticleDOI
Nitrite is a signaling molecule and regulator of gene expression in mammalian tissues
Nathan S. Bryan,Bernadette O. Fernandez,Selena Bauer,Maria F. Garcia-Saura,Alexandra B. Milsom,Tienush Rassaf,Tienush Rassaf,Ronald E. Maloney,Ajit Bharti,Juan Rodriguez,Martin Feelisch +10 more
TL;DR: In this article, it was shown that nitrite is remarkably efficient at modifying the same protein sites, and that physiological nitrite concentrations account for the basal levels of these modifications in vivo.
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Nitrite disrupts multiple physiological functions in aquatic animals.
TL;DR: Heart rate increases rapidly, before any significant elevations in metHb or extracellular potassium occur, suggesting nitrite-induced vasodilation (possibly via nitric oxide generated from nitrite) that is countered by increased cardiac pumping to re-establish blood pressure.
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Journal ArticleDOI
[Organotropic carcinogenic effects of 65 various N-nitroso- compounds on BD rats].
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DNA deaminating ability and genotoxicity of nitric oxide and its progenitors
David A. Wink,Kazimierz S. Kasprzak,Chris M. Maragos,Rosalie K. Elespuru,Manoj Misra,Tambra M. Dunams,Thomas A. Cebula,Walter H. Koch,A.W. Andrews,Jane Allen,Larry K. Keefer +10 more
TL;DR: Nitric oxide (NO), a multifaceted bioregulatory agent and an environmental pollutant, can also cause genomic alterations that may contribute to the incidence of deamination-related genetic disease and cancer.
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Vegetables, fruit, and cancer. I. Epidemiology.
TL;DR: The epidemiologic literature on the relationship between vegetable and fruit consumption and human cancer at a variety of sites is reviewed systematically and it is concluded that consumption of higher levels of vegetables and fruit is associated consistently, although not universally, with a reduced risk of cancer at most sites.
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DNA damage and mutation in human cells exposed to nitric oxide in vitro.
TL;DR: Experiments in which NO was added to intact human cells and to aerobic solutions of DNA, RNA, guanine, or adenine produced a 40- to 50-fold increase in hypoxanthine and xanthine in cellular DNA, which are believed to account for the mutagenicity of nitric oxide toward bacteria and mammalian cells.