Journal ArticleDOI
Normal- and Reversed-Phase Chromatography of para-Substituted Propanoic Acid Amides
TLDR
In this paper, the retention constants determined for the amides are discussed in terms of the physicochemical properties of the solute and the stationary and mobile phases, derived by extrapolation from retention in reversed-phase chromatography.Abstract:
The chromatographic behavior of newly synthesized para -substituted propanoic acid amides has been studied in normal- and reversed-phase thin-layer chromatography. The retention mechanism on different TLC supports was investigated. The retention constants determined for the amides are discussed in terms of the physicochemical properties of the solute and the stationary and mobile phases. R M,w , derived by extrapolation from retention in reversed-phase chromatography, was correlated with hydrophobic parameters π and log P , calculated by the Rekker fragmental method and by use of the commercial program ACD/log P .read more
Citations
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Journal ArticleDOI
Chromatographic evaluation of the lipophilic properties of selected pesticides
Alina Pyka,Marek Miszczyk +1 more
TL;DR: The most significant correlations were found between the chromatographic lipophilicities and C log P values and the valence Gutman index (M 1 ν 2 ) as mentioned in this paper, and a linear correlation was also obtained between lipophilicity (log kw, RMw, φo(HPLC), and φ o(TLC) calculated using five different software products.
Journal ArticleDOI
Lipophilicity of selected steroid compounds. I. Investigations on RP18W stationary phase by RP-HPTLC
Alina Pyka,M. Babuska +1 more
TL;DR: The results indicate that chromatographic parameters of lipophilicity may be used as a measure of lipphilicity of the investigated steroid compounds.
Journal ArticleDOI
Study of lipophilicity and application of selected topological indexes in QSAR analysis of nicotinic acid derivatives. Part I
TL;DR: A linear relationship was obtained between R M 0 and the slope, S, of the chromatography equation in this paper, and the most significant correlation was found between the R M0 and A log P s values.
Journal ArticleDOI
Effect of the physicochemical properties of N,N -disubstituted-2-phenylacetamide derivatives on their retention behavior in RP-TLC
TL;DR: In this article, the chromatographic lipophilicity R M 0 (determined by linear extrapolation) was correlated with log P values calculated by use of different theoretical methods.
Journal ArticleDOI
Lipophilicity of Selected Bile Acids as Determined by TLC. I
Alina Pyka,Małgorzata Dołowy +1 more
TL;DR: In this article, a linear relationship was found between R M values of bile acids and the volume fraction of methanol in the mobile phase, which indicated that chromatographic R MW values may be used as a measure of lipophilicity of the investigated bile acid compounds.
References
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Book
Substituent constants for correlation analysis in chemistry and biology
Corwin Hansch,Albert J. Leo +1 more
TL;DR: In this paper, the book is the window to get in the world and you can open the world easily, and these wise words are really familiar with you, so bring home now the book enPDFd substituent constants for correlation analysis in chemistry and biology to be your sources when going to read.
Journal ArticleDOI
p-σ-π Analysis. A Method for the Correlation of Biological Activity and Chemical Structure
Corwin Hansch,Toshio Fujita +1 more
Journal ArticleDOI
Solvent composition effects in thin-layer chromatography systems of the type silica gel-electron donor solvent
Journal ArticleDOI
Hydrophilic interaction chromatography using amino and silica columns for the determination of polar pharmaceuticals and impurities.
TL;DR: An examination of the retention and separation of several pyrimidines, purines, and amides on silica and amino columns from three manufacturers revealed that mobile phases should contain a buffer or acid for pH control to achieve similar and reproducible results among columns from different sources.
Journal ArticleDOI
Solvent composition effects in liquid-solid systems
TL;DR: In this paper, column chromatographic data reported by Scott and Kucera for systems of the type pentane + polar solvent (S)-silica result in linear plots of log V′ versus log Cs and are thus in agreement with adsorption models based on the law of mass action.