Journal ArticleDOI
Normalization of the growth hormone and catecholamine response to exercise in juvenile-onset diabetic subjects treated with a portable insulin infusion pump.
William V. Tamborlane,Robert S. Sherwin,Veikko A. Koivisto,Rosa Hendler,Myron Genel,Philip Felig +5 more
TLDR
Treatment of insulin-dependent diabetics with a subcutaneous portable insulin infusion system that normalizes plasma glucose results in normalization of the growth hormone and catecholamine response to exercise within 7 to 14 days of institution of treatment.Abstract:
The plasma growth hormone, epinephrine, and norephinephrine responses to cycle ergometer exercise (15 min at 1 W/kg) were examined in 10 juvenile-onset, insulin-dependent diabetics (ages 10–32 yr) during conventional insulin treatment and after 7 and 14 days of treatment with a portable subcutaneous insulin infusion system that normalizes plasma glucose. During conventional insulin treatment (mean plasma glucose, 205 ± 22 mg/dl), the growth hormone response to exercise was sevenfold greater than in normal controls (Pread more
Citations
More filters
Journal ArticleDOI
Physiology and Pathophysiology of the Human Sympathoadrenal Neuroendocrine System
TL;DR: The sympathoadrenal system is the prototype neuroendocrine system and norepinephrine is released from axon terminals of sympathetic postganglionic neurons and deposited directly at innervated target cells.
Journal ArticleDOI
Hyperglycemia Decreases Glucose Uptake in Type I Diabetes
TL;DR: Short-term hyperglycemia reduces glucose uptake in type I diabetic patients, which suggests that part of the glucose or insulin resistance in these patients may be caused by hyper glycemia per se.
Journal ArticleDOI
Importance of Raised Growth Hormone Levels in Mediating the Metabolic Derangements of Diabetes
TL;DR: The moderate elevations in growth hormone levels that occur in poorly controlled diabetes can themselves reproduce the whole spectrum of abnormal metabolic fuel concentrations that are associated with poor diabetic control, despite optimized insulin treatment.
Journal ArticleDOI
Effect of Diabetes and its Control on Insulin-like Growth Factors in the Young Subject with Type I Diabetes
Stephanie A Amiel,Robert S. Sherwin,Raymond L. Hintz,Joseph M. Gertner,C M Press,William V. Tamborlane +5 more
TL;DR: Elevated growth hormone levels in poorly controlled diabetes are ineffective in IGF I generation and that this defect is at least partially corrected by acute improvement in control, according to a study of 19 young, insulin-dependent subjects with diabetes mellitus.
Journal ArticleDOI
Growth hormone neuroregulation and its alterations in disease states
TL;DR: The effects of intranasal insufflation of growth hormone releasing factor analogue GRF (1-29) NH2 on growth hormone secretion in children with short stature and the dawn phenomenon in patients with insulin dependent diabetes mellitus are studied.
References
More filters
Journal ArticleDOI
A simplified radiometric assay for plasma norepinephrine and epinephrine.
Philip G. Passon,Jacob D. Peuler +1 more
TL;DR: The plasma norepinephrine and epinephrine assay, when compared to currently available methods, provides a substantial decrease in the assay time while providing a 10-fold increase in sensitivity which allows the analysis to be performed on 0.75 ml or less of plasma.
Journal ArticleDOI
Reduction to Normal of Plasma Glucose in Juvenile Diabetes by Subcutaneous Administration of Insulin with a Portable Infusion Pump
TL;DR: It is demonstrated that plasma glucose can be lowered to normal in ambulatory patients with brittle juvenile diabetes using a portable, subcutaneous insulin infusion system for two to four days.
Journal ArticleDOI
Glucagon and plasma catecholamine responses to graded and prolonged exercise in man.
TL;DR: Although increments in catecholamines were similar, the glucagon secretion was larger during prolonged than during graded exercise, they cannot account completely for the rise of glucagon during prolonged exercise.
Journal Article
Secretion of human growth hormone: physiologic and experimental modification
Journal ArticleDOI
Plasma Norepinephrine and Epinephrine in Untreated Diabetics, During Fasting and After Insulin Administration
TL;DR: Plasma norepinephrine rose as blood glucose concentrations decreased even in diabetics in whom values had not reached hypoglycemic levels, and no correlation was observed between plasma epinephrine and increase in pulse rate during hypoglycemia.