Journal ArticleDOI
North American Contact Dermatitis Group Patch Test Results 2013-2014
Joel G. DeKoven,Erin M. Warshaw,Donald V. Belsito,Denis Sasseville,Howard I. Maibach,James S. Taylor,James G. Marks,Joseph F. Fowler,C. G.Toby Mathias,Vince A. DeLeo,Melanie D. Pratt,Matthew J. Zirwas,Kathryn A. Zug +12 more
TLDR
The NACDG patch testing results confirm that the epidemic of sensitivity to methylisothiazolinone previously documented in Europe is also occurring in North America.Abstract:
Background Patch testing is the most important diagnostic tool for the assessment of allergic contact dermatitis. Objective This study documents the North American Contact Dermatitis Group (NACDG) patch testing results from January 1, 2013, to December 31, 2014. Methods At 13 centers in North America, patients were tested in a standardized manner with a screening series of 70 allergens. Data were manually verified and entered into a central database. Descriptive frequencies were calculated, and trends were analyzed using χ test. Results A total of 4871 patients were tested. There were 3255 patients (66.8%) who had at least 1 positive reaction and 2412 patients (49.5%) who were ultimately determined to have a primary diagnosis of allergic contact dermatitis. A total of 434 patients (8.9%) had occupationally related skin disease. There were 9726 positive allergic reactions. Compared with the previous reporting periods (2011-2012 and 2001-2012, including at least three 2-year cycles), positive reaction rates for the top 25 screening allergens statistically increased for 2 allergens: methylchloroisothiazolinone/methylisothiazolinone (6.4%; risk ratios, 1.26 [1.07-1.50] and 2.08 [1.84-2.37]) and hydroxyethyl methacrylate (2.6%; risk ratios, 1.34 [1.02-1.76] and 1.23 [1.00-1.51]). Methylisothiazolinone, which was added to the screening series for this 2013-2014 cycle, had the third highest positive reaction rate of allergens tested (10.9%). Four other newly added allergen preparations-formaldehyde 2% (7%), diphenylguanidine (3.8%), propylene glycol 100% (2.8%), and benzophenone-4 (2.1%)-all had reaction rates greater than 2%. Twenty-one percent of tested patients had at least 1 relevant allergic reaction to an allergen not on the NACDG series; 14.6% of these were occupationally related. The T.R.U.E. TEST (SmartPractice Denmark, Hillerod, Denmark) would have hypothetically missed one quarter to one third of reactions detected by the NACDG screening series. Conclusions These results confirm that the epidemic of sensitivity to methylisothiazolinone previously documented in Europe is also occurring in North America. Patch testing with allergens beyond a standard screening tray is necessary for the complete evaluation of occupational and nonoccupational allergic contact dermatitis.read more
Citations
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Journal ArticleDOI
North American Contact Dermatitis Group Patch Test Results: 2015-2016
Joel G. DeKoven,Erin M. Warshaw,Erin M. Warshaw,Kathryn A. Zug,Howard I. Maibach,Donald V. Belsito,Denis Sasseville,James S. Taylor,Joseph F. Fowler,C. G.Toby Mathias,James G. Marks,Melanie D. Pratt,Matthew J. Zirwas,Vincent A. DeLeo +13 more
TL;DR: The results confirm that the epidemic of sensitivity to methylisothiazolinone has continued in North America and that patch testing with allergens beyond a screening tray is necessary for a complete evaluation of occupational and nonoccupational ACD.
Journal ArticleDOI
Prevalence of contact allergy in the general population: A systematic review and meta-analysis.
TL;DR: Contact allergy and allergic contact dermatitis are frequent conditions in the general population and should not be considered a cause for concern.
Journal ArticleDOI
Parabens: Contact (Non)Allergen of the Year
Anthony F. Fransway,Fransway Pj,Donald V. Belsito,Erin M. Warshaw,Denis Sasseville,Joseph F. Fowler,Joel G. DeKoven,Pratt,Howard I. Maibach,James S. Taylor,James G. Marks,Mathias Cgt,Vincent A. DeLeo,Zirwas Jm,Kathryn A. Zug,Amber Reck Atwater,Jonathan I. Silverberg,Margo J. Reeder +17 more
TL;DR: The well-established safety of parabens from an allergologic standpoint is reviewed and paraben mix is selected as the (non)allergen of the year.
Journal ArticleDOI
North American Contact Dermatitis Group Patch Test Results: 2017-2018.
Joel G. DeKoven,Jonathan I. Silverberg,Erin M. Warshaw,Amber Reck Atwater,Margo J. Reeder,Denis Sasseville,James S. Taylor,Kathryn A. Zug,Donald V. Belsito,Howard I. Maibach,Melanie D. Pratt,Mathias Cgt,Vincent A. DeLeo,Joseph F. Fowler +13 more
TL;DR: In this paper, the authors documented the North American Contact Dermatitis Group (NACDG) patch testing results from March 1, 2017, to December 31, 2018, at 14 centers in North America, patients with dermatitis were tested in a standardized manner with a screening series of 70 allergens and supplemental allergens.
Journal ArticleDOI
Consumer Preferences, Product Characteristics, and Potentially Allergenic Ingredients in Best-Selling Moisturizers
TL;DR: Best-selling moisturizer products vary widely by price and product characteristics, and dermatologists should balance consumer preference, price, and allergenicity in their recommendations.
References
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Journal ArticleDOI
North American Contact Dermatitis Group patch test results, 2001-2002 study period
Melanie D. Pratt,Donald V. Belsito,Vincent A. DeLeo,Joseph F. Fowler,Anthony F. Fransway,Howard I. Maibach,James G. Marks,C. G.Toby Mathias,Robert L. Rietschel,Denis Sasseville,Elizabeth F. Sherertz,Frances J. Storrs,James S. Taylor,Kathryn A. Zug +13 more
TL;DR: The findings of patch testing from January 1, 2001, to December 31, 2002 reinforce the need for a more comprehensive group of diagnostic allergens than those found in the standard screening kits.
Journal ArticleDOI
Patch-test results of the North American Contact Dermatitis Group 2005-2006.
Kathryn A. Zug,Erin M. Warshaw,Joseph F. Fowler,Howard I. Maibach,Belsito Dl,Pratt,Denis Sasseville,F. J. Storrs,James S. Taylor,Mathias Cg,Vincent A. DeLeo,Robert L. Rietschel,James G. Marks +12 more
TL;DR: Nickel has been the most frequently positive allergen detected by the NACDG; rates significantlyincreased in the current study period and most reactions were clinically relevant.
Journal ArticleDOI
North American Contact Dermatitis Group patch test results: 2009 to 2010.
Erin M. Warshaw,Donald V. Belsito,James S. Taylor,Denis Sasseville,Joel G. DeKoven,Matthew J. Zirwas,Anthony F. Fransway,C. G.Toby Mathias,Kathryn A. Zug,Vincent A. DeLeo,Joseph F. Fowler,James G. Marks,Melanie D. Pratt,Frances J. Storrs,Howard I. Maibach +14 more
TL;DR: These results affirm the value of patch testing with many allergens and Hypothetically, approximately one quarter of reactions detected by NACDG allergens would have been missed by TRUE TEST (SmartPractice Denmark).
Journal ArticleDOI
North American Contact Dermatitis Group patch-test results, 1998 to 2000.
James G. Marks,Donald V. Belsito,Vincent A. DeLeo,Joseph F. Fowler,Anthony F. Fransway,Howard I. Maibach,C. G.Toby Mathias,Melanie D. Pratt,Robert L. Rietschel,Elizabeth F. Sherertz,Frances J. Storrs,James S. Taylor +11 more
TL;DR: The findings reinforce the need for a more comprehensive group of diagnostic allergens than is found in the T.R.E.U. TEST, which is sold in the United States.
Journal ArticleDOI
Guidelines for the descriptive presentation and statistical analysis of contact allergy data
TL;DR: Clinical researchers are supported in adequately presenting data on contact allergy, and to use statistical tests appropriate for their data, using standard measures like sensitivity and specificity as well as the prevalence‐dependent positive and negative predictive values.