Patent
Novel benzoxazinones as peroxisome proliferator activated receptor gamma modulators and method of treatment
TLDR
In this paper, a benzoxazinone derivatives useful as peroxisome proliferator activated receptor gamma (PPARη) modulators are described and compositions comprising compounds of the present invention and methods of treating conditions such as NIDDM and obesity are also disclosed.Abstract:
The invention is directed to benzoxazinone derivatives useful as peroxisome proliferator activated receptor gamma (PPARη) modulators. Pharmaceutical compositions comprising compounds of the present invention and methods of treating conditions such as NIDDM and obesity are also disclosed.read more
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Patent
Quinolinyl and benzothiazolyl modulators
Lawrence R. Mcgee,Jonathan B. Houze,Steven M. Rubenstein,Hagiwara Atsushi,Noboru Furukawa,Hisashi Shinkai +5 more
TL;DR: In this article, compounds, compositions and methods are provided that are useful in the treatment or prevention of a condition or disorder mediated by PPARγ, in particular, the compounds of the invention modulate the function of PPARαγ, which is particularly useful for the treatment and prevention of diabetes, obesity, hypercholesterolemia, rheumatoid arthritis and atherosclerosis.
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Salts and polymorphs of a potent antidiabetic compound
TL;DR: Salts and polymorphs of a compound useful in the treatment of inflammatory and metabolic conditions and diseases are provided in this article, which are useful for the treatment or prevention of conditions and disorders associated with energy homeostasis such as type II diabetes, lipid metabolism, adipocyte differentiation and inflammation.
Patent
COMPOUNDS FOR THE MODULATION OF PPARgamma ACTIVITY
TL;DR: In this paper, modulators of PPARγ activity are provided which are useful in pharmaceutical compositions and methods for the treatment of conditions such as type II diabetes and obesity, and they are used in clinical trials.
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Biologically active 4H-benzo [1,4]oxazin-3-ones
TL;DR: In this article, the authors proposed a peroxisome proliferator activated receptor gamma (PPARγ) agonists or antagonists for treating conditions such as NIDDM and obesity.
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Methods for avoiding edema in the treatment of metabolic, inflammatory, and cardiovascular disorders
Martin E. Sanders,David B. Karpf +1 more
TL;DR: In this article, the authors present compounds, compositions, and methods of treating or preventing edema, inflammatory disorders, pro-inflammatory states, or lowering CRP levels in subjects using edema-sparing PPARϜ modulators or phenoxyacetic acid derivatives.
References
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Journal ArticleDOI
Multiple Mechanisms of Action for Inhibitors of Histidine Protein Kinases from Bacterial Two-Component Systems
TL;DR: The antibacterial HPK inhibitors caused a rapid decrease in cellular incorporation of RNA, DNA, and protein precursors, possibly as a result of the concomitant disruption of the cytoplasmic membrane.
Patent
3-aryl-2-hydroxypropionic acid derivatives and analogs as hypoglycemic agents
TL;DR: In this paper, the authors used 3-(phenyl, chroman-2-yl, benzofuran-5-yl or benzoxazol-5yl)-2-(hydroxy or mercapto)propionic acid derivatives and analogs are useful as hypoglycemic and hypocholesterolemic agents.
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Bicyclic compounds, process for their preparation and pharmaceutical compositions containing them
Braj Bhushan Lohray,Vidya Bhushan Lohray,Ashok Channaveerappa Bajji,Shivaramayya Kalchar,Rajagopalan Ramanujam,Ranjan Chakrabarti +5 more
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Benzoxazoles and pyridine derivatives useful in the treatment of the type ii diabetes
TL;DR: A compound of formula (I) or a pharmaceutically acceptable salt thereof, and/or a pharmaceutical solvate thereof, wherein Ro represents 2-benzoxazolyl or 2-pyridyl and R1 represents CH?2?OCH3 or CF3; a process for the preparation of such compounds, a pharmaceutical composition containing such compounds and the use of these compounds and compositions in medicine as discussed by the authors.
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Benzoxazine antimicrobial agents
TL;DR: In this article, the authors described benzoxazine and pyrido-oxazine antibacterial compounds of general formula, wherein the moiety Q is a fused phenyl or fused pyridyl moiety.