Gaochao Zhou

TL;DR: It is reported that metformin activates AMPK in hepatocytes; as a result, acetyl-CoA carboxylase (ACC) activity is reduced, fatty acid oxidation is induced, and expression of lipogenic enzymes is suppressed.

TL;DR: Genetic and pharmacological studies demonstrate that AMPK is required for maintaining glucose homeostasis and holds a considerable potential to reverse the metabolic abnormalities associated with type 2 diabetes.

TL;DR: The findings suggest that the metabolic effects of metformin in subjects with type 2 diabetes may be mediated by the activation of AMPK alpha2, which is implicated in the stimulation of glucose uptake into skeletal muscle and the inhibition of liver gluconeogenesis.

TL;DR: 27-hydroxylation of cholesterol is an important pathway for LXR activation in response to cholesterol overload, and is concluded that 27-hydroxycholesterol functionally activated LXR.

TL;DR: Sustained GLP1R/GCGR dual agonism reverses obesity in DIO mice and is a novel therapeutic approach to the treatment of obesity.