Journal ArticleDOI
Novel method of activating thiols by their conversion into thionitrites with dinitrogen tetroxide
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The reaction of thiols with N2O4 in an inert organic solvent such as CCl4 or ether at low temperatures afforded aryl and alkyl thionitrites in quantitative yields.Abstract:
The reaction of thiols with N2O4 in an inert organic solvent such as CCl4 or ether at low temperatures afforded aryl and alkyl thionitrites in quantitative yields; the thionitrites thus obtained reacted very readily with other thiols or sulphinic acids to give unsymmetrical disulphides or thiolsulphonates in nearly quantitative yields.read more
Citations
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Journal ArticleDOI
Nitric Oxide Donors: Chemical Activities and Biological Applications
Journal ArticleDOI
Biological chemistry and clinical potential of S-nitrosothiols.
TL;DR: The biological chemistry, biological actions, and clinical potential of S-nitrosothiols are described, highlighting the fact that these compounds are more than simply nitric oxide donors.
Book ChapterDOI
S-Nitrosothiols and the Bioregulatory Actions of Nitrogen Oxides Through Reactions with Thiol Groups
TL;DR: The data presented here support the idea that RS-NO may be involved in stabilizing nitric oxide-like bioactivity, in transporting and targeting the NO group to specific (thioregulatory) effector sites, in mitigating the cytotoxic effects ofNitric oxide that result from reaction with oxygen species, and may serve to regulate protein function in a posttranslational modification akin, perhaps, to phosphorylation.
Journal ArticleDOI
Stimulation of endothelial nitric oxide production by homocyst (e) ine
Gilbert R. Upchurch,Gilbert R. Upchurch,George N. Welch,Attila J. Fabian,Alessio Pigazzi,John F. Keaney,Joseph Loscalzo +6 more
TL;DR: In this paper, the authors showed that in the presence of an NO agonist, HCY increases RSNO production in a time and dose-dependent fashion that is reflected by an increase in eNOS activity and Nos 3 transcription.