Attila J. Fabian

TL;DR: It is shown that enforced Tert or PGC-1α expression or germline deletion of p53 substantially restores PGC network expression, mitochondrial respiration, cardiac function and gluconeogenesis in the setting of telomere dysfunction.

TL;DR: It is shown that Hcy treatment of bovine aortic endothelial cells leads to a dose-dependent decrease in NO x independent of endothelial nitric-oxide synthase activity or protein levels and nos3 transcription, suggesting that HCy affects the bioavailability of NO, not its production.

TL;DR: EPCR represents the first known marker that 'explicitly' identifies hematopoietic stem cells within murine bone marrow, and evaluation of cell populations first enriched for stem cell activity by conventional methods and subsequently fractionated on the basis of EPCR expression indicates that stemcell activity is always associated with EPCr-expressing cells.

TL;DR: It is demonstrated that when autofluorescence, dead cells, and contaminating blood cells are excluded from analysis, there is no detectable reconstitution of lung alveolar epithelial cells by unfractionated bone marrow cells or purified hematopoietic stem cells.

TL;DR: An important function for the nNOS isoform is demonstrated in controlling the inducibility of airway hyperresponsiveness in this model of allergic asthma.