Nuclear morphometry as an important prognostic factor in stage I renal cell carcinoma
Piero Tosi,Pietro Luzi,Jan P. A. Baak,Clelia Miracco,Rosa Santopietro,Carla Vindigni,F. M. Mattei,Angelo Acconcia,Maria Rita Massai +8 more
TLDR
The results show the essential prognostic value of morphometry in this set of patients with Stage I renal cell carcinoma, where none of the 24 short‐term survivors are below that threshold and three of the long-term survivors exceed that value.Abstract:
Although 60% of Stage I renal carcinoma patients die from tumor within 5 years postoperatively, a considerable percentage survive that period. Nuclear grading can help to predict the outcome, but many of the patients are Grade 2, and the prognosis of this subclass is uncertain. Therefore, nuclear morphometry was carried out in 41 patients with Stage I renal cell carcinoma. Of these, 24 died within 5 years and 17 have survived that period. Using a mean nuclear area of 32 micron 2 as the decision threshold, none of the 24 short-term survivors are below that threshold and three of the long-term survivors exceed that value (18% false-positives) (99% confidence limit). Separate analysis with sets for learning and testing and Grade 2 patients gave similar results. The results show the essential prognostic value of morphometry in this set of patients with Stage I renal cell carcinoma.read more
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Prognostic factors in renal cancer
J B Thrasher,David F. Paulson +1 more
TL;DR: The accumulated data indicate that the local extent of a renal carcinoma at the time of surgical intervention is the most important single variable in determining survival.
Journal ArticleDOI
Original Articles: Kidney Cancer: Renal Cell Carcinoma: Tumor Size, Stage and Survival
Patrick Guinan,Nicholas J. Vogelzang,Amy M. Fremgen,Joan S. Chmiel,JoAnne Sylvester,Stephen F. Sener,Joseph P. Imperato +6 more
TL;DR: In an attempt to define the relationship among tumor size, stage and survival, the Cancer Incidence and End Results Committee of the American Cancer Society, Illinois Division, Inc. as mentioned in this paper reviewed the records of 2,473 patients with a histological diagnosis of renal cell carcinoma.
Journal ArticleDOI
Impact of tumor size on the clinical outcomes of patients with Robson Stage I renal cell carcinoma
Toshiaki Kinouchi,Shigeru Saiki,Norio Meguro,Osamu Maeda,Masao Kuroda,Michiyuki Usami,Toshihiko Kotake +6 more
TL;DR: In this article, the authors examined the impact of tumor size on the clinical outcomes of patients with Robson Stage I disease to determine a size cutoff that would maximize the predictive value of the TNM staging system.
Impact of tumor size on the clinical outcomes of patients with Robson Stage I renal cell carcinoma
Toshiaki Kinouchi,Shigeru Saiki,Norio Meguro,Osamu Maeda,Masao Kuroda,Michiyuki Usami,Toshihiko Kotake +6 more
TL;DR: The authors examined the impact of tumor size on the clinical outcomes of patients with Robson Stage I disease to determine a size cutoff that would maximize the predictive value of the TNM staging system.
Journal ArticleDOI
Prognostic factors in renal cell and bladder cancer.
Van Brussel,Mickisch +1 more
TL;DR: The clinical use of tissue-related prognostic factors system, which explicitly defines the anatomical extent of disease, is the most commonly used staging or have been studied in clinical trials, is discussed.
References
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Probability and statistics
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Journal ArticleDOI
Prognostic significance of morphologic parameters in renal cell carcinoma.
TL;DR: Nuclear grade was the most significant prognostic criterion for the outcome of State I renal cell carcinoma, more effective than each of the other parameters in predicting development of distant metastasis following nephrectomy.
Journal ArticleDOI
The value of morphometry to classic prognosticators in breast cancer.
TL;DR: In 271 breast cancer patients with adequate follow‐up for at least 5.5 and maximally 12 years, the value of morphometry to classic prognosticators of breast cancer was assessed and it was found that mitotic activity index is the best single predictor of the prognosis.