Patent
Nucleic acid hybridization assay for hepatitis B virus DNA
Michael S. Urdea,Warner Brian D,Joyce A. Running,Janice A. Kolberg,Jennifer M. Clyne,Ray Sanchez-Pescador,Thomas Horn +6 more
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TLDR
Linear or branched oligonucleotide multimers are useful as amplifiers in biochemical assays which comprise (1) at least one first single-stranded oligonotide unit that is complementary to a singlestranded sequence of interest, and (2) a multiplicity of second single strand-linked oligon nucleotide units that are complementary to the label of interest as mentioned in this paper.Abstract:
Linear or branched oligonucleotide multimers useful as amplifiers in biochemical assays which comprise (1) at least one first single-stranded oligonucleotide unit that is complementary to a single-stranded oligonucleotide sequence of interest, and (2) a multiplicity of second single-stranded oligonucleotide units that are complementary to a single-stranded labeled oligonucleotide. Amplified sandwich nucleic acid hybridizations and immunoassays using the multimers are exemplified.read more
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References
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Patent
Nucleotide analogs for nucleic acid labeling and detection
TL;DR: In this paper, nucleotide analogs, modified by the attachment at hydrogen bonding positions of linker groups, that is, the 6position of adenine, 4position of cytosine, and 2position of guanine, are prepared.
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Detection of microbial nucleic acids by a one-step sandwich hybridization test
TL;DR: In this paper, a diagnostic kit based on a one-step hybridization procedure and method of using the kit for identifying the nucleic acids of viruses and bacteria contained in a single sample.
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Preferential signal production on a surface in immunoassays
TL;DR: In this paper, the authors present a method for determining the presence of an analyte in a sample using a test strip and a signal-generating system, where the analyte is a member of an immunological pair (mip) of immunogens.
Patent
Replicative rna reporter systems.
TL;DR: In this article, the authors present a method for assaying for biopolymers, such as by immunoassay or nucleic acid probe hybridization assay, and compositions for carrying out the methods.
Patent
Hybridization method for the detection of genetic materials
TL;DR: In this article, the authors presented methods for the detection of a target genetic material having a desired base sequence or gene, which are based upon techniques which utilize two labeled single stranded polynucleotide segments which are complementary to the same or the opposite strands of the target GA material.