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Obstetric emergencies precipitated by malignant brain tumors.

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TLDR
To minimize temporal lobe or cerebellar herniation in neurologically unstable patients, a consideration should be made for cesarean delivery with the patient under general anesthesia, followed by immediate neurosurgical decompression.
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This article is published in American Journal of Obstetrics and Gynecology.The article was published on 2000-05-01 and is currently open access. It has received 99 citations till now. The article focuses on the topics: Pregnancy & Brain tumor.

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Citations
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Journal ArticleDOI

Obstetrical deliveries associated with maternal malignancy in California, 1992 through 1997.

TL;DR: In this paper, the rate of occurrence and nature of outcomes associated with obstetrical deliveries in women with malignant neoplasms among 3,168,911 women who delivered in California in 1992 through 1997.
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Pregnancy increases the growth rates of World Health Organization grade II gliomas.

TL;DR: Pregnancy increases the radiological growth rates of GIIGs, and an increase in seizure frequency was observed concomitantly in 40% of cases and further oncological treatment was started after delivery in 25% of Cases.
Journal ArticleDOI

Management strategy for brain tumour diagnosed during pregnancy

TL;DR: The best moment to recommend the craniotomy and the neurosurgical removal of the tumours will depend of the mother's neurological condition, the tumour histological type as well as the gestational age.
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The clinical management of intracranial neoplasms in pregnancy.

TL;DR: The presentation of intracranial tumors during pregnancy is relatively uncommon, but the care of these patients poses specific diagnostic and therapeutic challenges that are best managed by a multidisciplinary team of physicians prepared to implement a comprehensive approach to the problematic issues brain tumors raise in pregnant patients.
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Neurosurgery and pregnancy.

TL;DR: The care of a pregnant woman with a neurosurgical condition requires coherent teamwork between the obstetrician, neurosurgeon and neuroanaesthetist, and complex decisions will often need to be made with a significant lack in class 1, or even 2, evidence.
References
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Journal ArticleDOI

Pregnancy-Related Primary Brain and Spinal Tumors

TL;DR: It is concluded that different types of tumors are influenced at different stages of pregnancy, with gliomas and spinal vascular tumors accumulating in the first and third trimesters, respectively, while meningiomas gradually tends to increase during pregnancy.
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Brain tumor and pregnancy

TL;DR: There may be a relation between pregnancy hormones and the rate of brain tumor growth mediated through specific intracellular receptors, and management of brain tumors should be tailored to the individual patient.
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Newly diagnosed primary intracranial neoplasms in pregnant women: a population-based assessment.

TL;DR: The presence of a pregnancy at the time of the initial diagnosis of an intracranial neoplasm was studied using material from a population-based tumour registry, and review of this uniformly collected material did not provide support for the view that intruder neoplasms present more often during pregnancy.
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Fetal dose estimates for radiotherapy of brain tumors during pregnancy

TL;DR: Brain tumors may be irradiated to high dose during pregnancy resulting in fetal exposure < 0.10 Gy, conferring an increased but acceptable risk of leukemia in the child, but no other deleterious effects to the fetus after the fourth week of gestation.
Journal ArticleDOI

Tumors of the brain complicating pregnancy.

TL;DR: In the course of a neurosurgical practice, many problems aside from the brain tumor in question arise to plague the physician, but none is more baffling than that presented when a pregnant woman is found to harbor a tumor in her brain.
Related Papers (5)
Frequently Asked Questions (11)
Q1. What tumor subtypes were found in the antenatal cases?

Histologic tumor subtypes included glioblastoma multiforme (n = 4), anaplastic astrocytoma (n = 3), and metastatic breast carcinoma (n = l). 

Intractable nausea and vomiting were most commonly encountered (n = 3), but severe headache, gait disturbance, seizure disorder, urinary incontinence, memory loss, and paralysis were also observed. 

If acute clinical deterioration or impending herniation manifests, to avoid fetal wastage, expeditious delivery of the baby should be accomplished by cesarean with the patient under general anesthesia, followed by cerebral decompression and tumor resection. 

Patients in whom a brain tumor is discovered should receive corticosteroids to diminish cerebral edema (if present), and delivery should be accomplished expeditiously. 

After documentation of fetal pulmonary maturity by amniotic fluid analyses, both women were delivered of their infants electively by cesarean while they were under general anesthesia at 32 and 35 weeks’ gestation. 

Tarnow concluded that the prognosis of the pregnancy would be favorable provided the tumor was neither malignant nor infratentorial. 

12 Whereas cerebral metastases have long been recognized as a poor prognostic factor in gestational trophoblastic disease, it is disconcerting that, among the >50 cases of postterm choriocarcinoma associated with intracranial metastases, only 4 survivors (including 1 from this study) have been recorded in the medical literature. 

In 4 of their cases the tumors were malignant, and although 3 did not require an interruption in pregnancy, 2 of the mothers died within 1 year of delivery with inoperable tumors. 

The neonatal outcomes among these 6 cases with emergent delivery included 5 viable infants with birthweights of 988 to 4020 g, each of whom had an uneventful course in the neonatal intensive care unit. 

Two of the 10 cases were encountered during the postpartum period and consisted of intracranial metastatic gestational choriocarcinoma, occurring in women aged 26 and 21 years. 

If symptoms worsen, new deficits manifest, or there is evidence of increased tumor growth or metastases, radiotherapy during pregnancy may be contemplated with a calculation of radiation scatter to the fetus by phantom measurements.