Journal ArticleDOI
Obstructive sleep apnea as a risk factor for stroke and death.
H. Klar Yaggi,John Concato,Walter N. Kernan,Judith H. Lichtman,Lawrence M. Brass,Vahid Mohsenin +5 more
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The obstructive sleep apnea syndrome significantly increases the risk of stroke or death from any cause, and the increase is independent of other risk factors, including hypertension.Abstract:
background Previous studies have suggested that the obstructive sleep apnea syndrome may be an important risk factor for stroke. It has not been determined, however, whether the syndrome is independently related to the risk of stroke or death from any cause after adjustment for other risk factors, including hypertension. methods In this observational cohort study, consecutive patients underwent polysomnography, and subsequent events (strokes and deaths) were verified. The diagnosis of the obstructive sleep apnea syndrome was based on an apnea–hypopnea index of 5 or higher (five or more events per hour); patients with an apnea–hypopnea index of less than 5 served as the comparison group. Proportional-hazards analysis was used to determine the independent effect of the obstructive sleep apnea syndrome on the composite outcome of stroke or death from any cause. results Among 1022 enrolled patients, 697 (68 percent) had the obstructive sleep apnea syndrome. At baseline, the mean apnea–hypopnea index in the patients with the syndrome was 35, as compared with a mean apnea–hypopnea index of 2 in the comparison group. In an unadjusted analysis, the obstructive sleep apnea syndrome was associated with stroke or death from any cause (hazard ratio, 2.24; 95 percent confidence interval, 1.30 to 3.86; P=0.004). After adjustment for age, sex, race, smoking status, alcohol-consumption status, body-mass index, and the presence or absence of diabetes mellitus, hyperlipidemia, atrial fibrillation, and hypertension, the obstructive sleep apnea syndrome retained a statistically significant association with stroke or death (hazard ratio, 1.97; 95 percent confidence interval, 1.12 to 3.48; P=0.01). In a trend analysis, increased severity of sleep apnea at baseline was associated with an increased risk of the development of the composite end point (P=0.005). conclusions The obstructive sleep apnea syndrome significantly increases the risk of stroke or death from any cause, and the increase is independent of other risk factors, including hypertension.read more
Citations
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Reliability of upper pharyngeal airway assessment using dental CBCT: a systematic review
TL;DR: Only limited aspects of the process of airway analysis have been evaluated, indicating that further research is required to adequately establish the reliability of upper pharyngeal airway assessment of patients using dental CBCT.
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Prevalence of Sleep Apnea in Patients With Keratoconus
TL;DR: A striking number of patients without previous diagnosis of OSA seem to be at high risk for developing OSA, supporting the recommendation for a greater awareness among clinicians who might otherwise overlook this systemic condition and its consequences.
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The effect of gender on the prevalence of hypertension in obstructive sleep apnea
TL;DR: It is shown that the prevalence of hypertension increases with increasing age and severity of OSA, and markedly obese men may have a nearly 2-fold greater risk for hypertension than women in this clinic-based population.
Journal ArticleDOI
The high prevalence of obstructive sleep apnea among patients with bipolar disorders
TL;DR: The data suggest that unrecognized OSA may play a major role in the mortality and morbidity of bipolar disorders and all patients diagnosed with a bipolar disorder should be screened with an OSA questionnaire.
Journal ArticleDOI
Symptoms and risk of obstructive sleep apnea in primary care patients in Jordan
Basheer Khassawneh,Mohammad Ghazzawi,Yousef Khader,Mousa Alomari,Zouhair Amarin,Bashar Shahrour,Mohanad Hammouda +6 more
TL;DR: Obstructive sleep apnea, snoring, and daytime sleepiness were common among Jordanian patients attending primary care clinics and age of ≥30 years, chronic nasal congestion and illiteracy were associated with an increased risk of OSA.
References
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Journal ArticleDOI
The Occurrence of Sleep-Disordered Breathing among Middle-Aged Adults
TL;DR: The prevalence of undiagnosed sleep-disordered breathing is high among men and is much higher than previously suspected among women, and is associated with daytime hypersomnolence.
Journal Article
Sleep-related breathing disorders in adults: Recommendations for syndrome definition and measurement techniques in clinical research
W. Ward Flemons,Daniel J. Buysse,Susan Redline,A. Oack,Kingman P. Strohl,John R. Wheatley,Terry Young,Neil J. Douglas,Patrick Levy,W. McNicolas,John A. Fleetham,David P. White,W. Schmidt-Nowarra,D. Carley,J. Romaniuk +14 more
Journal ArticleDOI
Prospective study of the association between sleep-disordered breathing and hypertension.
TL;DR: A dose-response association between sleep-disordered breathing at base line and the presence of hypertension four years later was found that was independent of known confounding factors and suggest that sleep- disordered breathing is likely to be a risk factor for hypertension and consequent cardiovascular morbidity in the general population.
Journal ArticleDOI
Mortality by cause for eight regions of the world: Global Burden of Disease Study
TL;DR: The Global Burden of Disease Study (GBD) used various data sources and made corrections for miscoding of important diseases (eg, ischaemic heart disease) to estimate worldwide and regional cause-of-death patterns in 1990, and the estimates by cause provide a foundation for a more informed debate on public-health priorities.