Journal ArticleDOI
One-Year Follow-up of Platelet-Rich Plasma Treatment in Chronic Achilles Tendinopathy A Double-Blind Randomized Placebo-Controlled Trial
Suzan de Jonge,Robert J. de Vos,Adam Weir,Hans T. M. van Schie,Hans T. M. van Schie,Sita M A Bierma-Zeinstra,Jan A N Verhaar,Harrie Weinans,Harrie Weinans,Johannes L. Tol +9 more
TLDR
This randomized controlled trial showed no clinical and ultrasonographic superiority of platelet-rich plasma injection over a placebo injection in chronic Achilles tendinopathy at 1 year combined with an eccentric training program.Abstract:
Background: Achilles tendinopathy is a common disease among both athletes and in the general population in which the use of platelet-rich plasma has recently been increasing. Good evidence for the use of this autologous product in tendinopathy is limited, and data on longer-term results are lacking. Purpose: To study the effects of a platelet-rich plasma injection in patients with chronic midportion Achilles tendinopathy at 1-year follow-up. Study Design: Randomized controlled trial; Level of evidence, 1. Methods: Fifty-four patients, aged 18 to 70 years, with chronic tendinopathy 2 to 7 cm proximal to the Achilles tendon insertion were randomized to receive either a blinded injection containing platelet-rich plasma or saline (placebo group) in addition to an eccentric training program. The main outcome was the validated Victorian Institute of Sports Assessment–Achilles score. Patient satisfaction was recorded and ultrasound examination performed at baseline and follow-up. Results: The mean Victorian Institute of Sports Assessment–Achilles score improved in both the platelet-rich plasma group and the placebo group after 1 year. There was no significant difference in increase between both groups (adjusted between-group difference, 5.5; 95% confidence interval, –4.9 to 15.8, P = .292). In both groups, 59% of the patients were satisfied with the received treatment. Ultrasonographic tendon structure improved significantly in both groups but was not significantly different between groups (adjusted between-group difference, 1.2%; 95% confidence interval, –4.1 to 6.6, P = .647). Conclusion: This randomized controlled trial showed no clinical and ultrasonographic superiority of platelet-rich plasma injection over a placebo injection in chronic Achilles tendinopathy at 1 year combined with an eccentric training program.read more
Citations
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Journal ArticleDOI
Platelet-rich plasma: the PAW classification system.
TL;DR: A simple method for organizing and comparing results in the literature is proposed and is based on 3 components: the absolute number of Platelets, the manner in which platelet Activation occurs, and the presence or absence of White cells.
Journal ArticleDOI
A Call for Standardization in Platelet-Rich Plasma Preparation Protocols and Composition Reporting: A Systematic Review of the Clinical Orthopaedic Literature.
Jorge Chahla,Mark E. Cinque,Nicolas S. Piuzzi,Sandeep Mannava,Andrew G. Geeslin,Iain R. Murray,Grant J. Dornan,George F. Muschler,Robert F. LaPrade +8 more
TL;DR: Reporting of PRP preparation protocols in clinical studies is highly inconsistent, and the majority of studies did not provide sufficient information to allow the protocol to be reproduced, which does not enable comparison of the PRP products being delivered to patients.
Journal ArticleDOI
The Effectiveness of Platelet-Rich Plasma in the Treatment of Tendinopathy A Meta-analysis of Randomized Controlled Clinical Trials
TL;DR: There is good evidence to support the use of a single injection of LR-PRP under ultrasound guidance in tendinopathy, and both the preparation and intratendinous injection technique of PRP appear to be of great clinical significance.
Journal ArticleDOI
Platelet-Rich Plasma Injections in the Treatment of Chronic Rotator Cuff Tendinopathy A Randomized Controlled Trial With 1-Year Follow-up
TL;DR: At 1-year follow-up, a PRP injection was found to be no more effective in improving quality of life, pain, disability, and shoulder range of motion than placebo in patients with chronic RCT who were treated with an exercise program.
Journal ArticleDOI
Platelet rich therapies for musculoskeletal soft‐tissue injuries
Vinícius Ynoe de Moraes,Mario Lenza,Marcel Jun Sugawara Tamaoki,Flávio Faloppa,João Carlos Belloti +4 more
TL;DR: The effects (benefits and harms) of platelet-rich therapies for treating musculoskeletal soft tissue injuries were assessed and primary outcomes were functional status, pain and adverse effects.
References
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Journal ArticleDOI
Heavy-Load Eccentric Calf Muscle Training For the Treatment of Chronic Achilles Tendinosis
TL;DR: The treatment model with heavy-load eccentric calf muscle training has a very good short-term effect on athletes in their early forties.
Journal ArticleDOI
Platelet Quantification and Growth Factor Analysis from Platelet-Rich Plasma: Implications for Wound Healing
TL;DR: A variety of potentially therapeutic growth factors were detected and released from the platelets in significant levels in platelet-rich plasma preparations and may be capable of expediting wound healing in a variety of as yet undetermined specific wound applications.
Journal ArticleDOI
Histopathology of common tendinopathies. Update and implications for clinical management.
TL;DR: The histopathological findings in athletes with overuse tendinopathies are consistent with those in tendinosis — a degenerative condition of unknown aetiology, which may have implications for the prognosis and timing of a return to sport after experiencing tendon symptoms.
Journal ArticleDOI
Treatment of Chronic Elbow Tendinosis With Buffered Platelet-Rich Plasma
Allan Mishra,Terri Pavelko +1 more
TL;DR: Treatment of patients with chronic elbow tendinosis with buffered platelet-rich plasma reduced pain significantly in this pilot investigation and should be considered before surgical intervention.
Journal ArticleDOI
Platelet-rich plasma injection for chronic Achilles tendinopathy: a randomized controlled trial.
Robert J. de Vos,Adam Weir,Hans T. M. van Schie,Sita M A Bierma-Zeinstra,Jan A N Verhaar,Harrie Weinans,Johannes L. Tol +6 more
TL;DR: Among patients with chronic Achilles tendinopathy who were treated with eccentric exercises, a PRP injection compared with a saline injection did not result in greater improvement in pain and activity, and was not significantly different between both groups.