Journal ArticleDOI
A Call for Standardization in Platelet-Rich Plasma Preparation Protocols and Composition Reporting: A Systematic Review of the Clinical Orthopaedic Literature.
Jorge Chahla,Mark E. Cinque,Nicolas S. Piuzzi,Sandeep Mannava,Andrew G. Geeslin,Iain R. Murray,Grant J. Dornan,George F. Muschler,Robert F. LaPrade +8 more
TLDR
Reporting of PRP preparation protocols in clinical studies is highly inconsistent, and the majority of studies did not provide sufficient information to allow the protocol to be reproduced, which does not enable comparison of the PRP products being delivered to patients.Abstract:
Background:Platelet-rich plasma (PRP) is a blood-derived preparation whose use has grown exponentially in orthopaedic practice. However, there remains an unclear understanding of the biological properties and effects of PRP on musculoskeletal healing. Heterogeneous processing methods, unstandardizedread more
Citations
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A review of biomaterials in bone defect healing, remaining shortcomings and future opportunities for bone tissue engineering: The unsolved challenge.
TL;DR: This review aims to provide an overview on endogenous cascades of bone material formation and how these are transferred to new perspectives in biomaterial-driven approaches in bone regeneration.
Journal ArticleDOI
Intra-articular treatment options for knee osteoarthritis
TL;DR: Current and future intra-articular therapies for knee OA are critically appraise and generally positive efficacy conclusions concerning mesenchymal ‘stem’ cell therapy for knee cartilage pathology might be overstated owing to selective outcome reporting.
Journal ArticleDOI
Platelet-Rich Plasma: New Performance Understandings and Therapeutic Considerations in 2020.
TL;DR: Recent developments regarding PRP preparation and composition regarding platelet dosing, leukocyte activities concerning innate and adaptive immunomodulation, serotonin (5-HT) effects, and pain killing are discussed.
Journal ArticleDOI
Platelet Rich Plasma: New Insights for Cutaneous Wound Healing Management
Deborah Chicharro-Alcántara,Mónica Rubio-Zaragoza,Elena Damiá-Giménez,José M. Carrillo-Poveda,Belén Cuervo-Serrato,Pau Peláez-Gorrea,Joaquín J. Sopena-Juncosa +6 more
TL;DR: This article reviews the emerging field of skin wound regenerative therapies with particular emphasis on PRP and the role of growth factors in the wound healing process.
Journal ArticleDOI
Optimizing Clinical Use of Biologics in Orthopaedic Surgery: Consensus Recommendations From the 2018 AAOS/NIH U-13 Conference.
Constance R. Chu,Scott A. Rodeo,Nidhi Bhutani,Laurie R. Goodrich,Johnny Huard,James J. Irrgang,Robert F. LaPrade,Christian Lattermann,Ying Lu,Bert R. Mandelbaum,Jeremy J. Mao,Louis F McIntyre,Allan Mishra,George F. Muschler,Nicolas S. Piuzzi,Hollis G. Potter,Kurt P. Spindler,John M. Tokish,Rocky S. Tuan,Kenneth Zaslav,William J. Maloney +20 more
TL;DR: The American Academy of Orthopaedic Surgeons (AOAOS) as mentioned in this paper has established a consensus framework for improving and accelerating the clinical evaluation, use, and optimization of biologic therapies for musculoskeletal diseases.
References
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Journal ArticleDOI
Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement
TL;DR: Moher et al. as mentioned in this paper introduce PRISMA, an update of the QUOROM guidelines for reporting systematic reviews and meta-analyses, which is used in this paper.
Journal ArticleDOI
Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement
TL;DR: PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) is introduced, an update of the QUOROM guidelines for reporting systematic reviews and meta-analyses.
Journal ArticleDOI
Treatment of Chronic Elbow Tendinosis With Buffered Platelet-Rich Plasma
Allan Mishra,Terri Pavelko +1 more
TL;DR: Treatment of patients with chronic elbow tendinosis with buffered platelet-rich plasma reduced pain significantly in this pilot investigation and should be considered before surgical intervention.
Journal ArticleDOI
Platelet-rich plasma injection for chronic Achilles tendinopathy: a randomized controlled trial.
Robert J. de Vos,Adam Weir,Hans T. M. van Schie,Sita M A Bierma-Zeinstra,Jan A N Verhaar,Harrie Weinans,Johannes L. Tol +6 more
TL;DR: Among patients with chronic Achilles tendinopathy who were treated with eccentric exercises, a PRP injection compared with a saline injection did not result in greater improvement in pain and activity, and was not significantly different between both groups.